Plasma levels of the arterial wall protein fibulin-1 are associated with carotid-femoral pulse wave velocity: a cross-sectional study
| العنوان: | Plasma levels of the arterial wall protein fibulin-1 are associated with carotid-femoral pulse wave velocity: a cross-sectional study |
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| المؤلفون: | Jens Sandahl Christiansen, Esben Laugesen, Per Løgstrup Poulsen, Pernille Høyem, Troels Krarup Hansen, Klavs Würgler Hansen, W. Scott Argraves, Lars Melholt Rasmussen, Søren Tang Knudsen |
| المصدر: | Laugesen, E, Høyem, P, Christiansen, J S, Knudsen, S T, Hansen, K W, Argraves, W S, Hansen, T K, Poulsen, P L & Rasmussen, L M 2013, ' Plasma levels of the arterial wall protein fibulin-1 are associated with carotid-femoral pulse wave velocity : a cross-sectional study ', Cardiovascular Diabetology, vol. 12, 107 . https://doi.org/10.1186/1475-2840-12-107Test Laugesen, E, Høyem, P, Christiansen, J S, Knudsen, S T, Hansen, K W, Argraves, W S, Hansen, T K, Poulsen, P L & Rasmussen, L M 2013, ' Plasma levels of the arterial wall protein fibulin-1 are associated with carotid-femoral pulse wave velocity : a cross-sectional study ', Cardiovascular Diabetology, vol. 12, no. 1, pp. 107 . https://doi.org/10.1186/1475-2840-12-107Test Cardiovascular Diabetology |
| بيانات النشر: | Springer Nature |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Pathology, Endocrinology, Diabetes and Metabolism, Renal function, Type 2 diabetes, Pulse Wave Analysis, Calcium-Binding Proteins/blood, Vascular Stiffness, Predictive Value of Tests, Risk Factors, Internal medicine, Diabetes mellitus, Heart rate, Type 2 diabetes mellitus, medicine, Humans, Pulse wave velocity, Original Investigation, Aged, Immunoassay, business.industry, Fibulin-1, Calcium-Binding Proteins, Type 2 Diabetes Mellitus, Middle Aged, medicine.disease, Carotid Arteries/physiopathology, Arterial stiffness, Pulse pressure, Femoral Artery, Diabetic Angiopathies/blood, Carotid Arteries, Cross-Sectional Studies, Diabetes Mellitus, Type 2, Case-Control Studies, Multivariate Analysis, Cardiology, business, Diabetes Mellitus, Type 2/blood, Femoral Artery/physiopathology, Cardiology and Cardiovascular Medicine, Biomarkers, Diabetic Angiopathies, Biomarkers/blood |
| الوصف: | Background: The arterial system in diabetic patients is characterized by generalized non-atherosclerotic alterations in the vascular extracellular matrix causing increased arterial stiffness compared with subjects without diabetes. The underlying pathophysiology remains elusive. The elastin-associated extracellular matrix protein, fibulin-1, was recently found in higher concentrations in the arterial wall and in plasma in patients with long duration type 2 diabetes. Furthermore, plasma fibulin-1 independently predicted total mortality and was associated with pulse pressure, an indirect measure of arterial stiffness. Whether plasma fibulin-1 is associated with arterial stiffness at earlier phases of type 2 diabetes has not been determined.Methods: In this cross-sectional study, we examined 90 patients with recently diagnosed type 2 diabetes (< 5 years) and 90 gender- and age-matched controls. Plasma fibulin-1 was measured immunochemically. Arterial stiffness was assessed by carotid-femoral Pulse Wave Velocity (PWV). Differences in means were assessed by t-tests. Associations were assessed by multivariate regression analyses.Results: Plasma fibulin-1 levels were lower in the diabetic group compared with the control group, 93 ± 28 vs 106 ± 30 μg/mL, p = 0.005. In unadjusted analysis of the total study sample, plasma fibulin-1 was not associated with PWV, p = 0.46. However, with adjustment for the confounders age, gender, mean blood pressure, heart rate, body mass index, diabetes and glomerular filtration rate, a 10 μg/mL increase in plasma fibulin was associated with 0.09 ± 0.04 m/s increase in PWV, p < 0.05. In subgroup analysis, plasma fibulin-1 was associated with PWV in the diabetes group, (0.16 ± 0.07 m/s increase in PWV per 10 μg/mL increase in plasma fibulin-1, p |
| اللغة: | English |
| تدمد: | 1475-2840 |
| DOI: | 10.1186/1475-2840-12-107 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1327fdf0e2198daef04780499b88ab10Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....1327fdf0e2198daef04780499b88ab10 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14752840 |
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| DOI: | 10.1186/1475-2840-12-107 |