Empagliflozin influences blood viscosity and wall shear stress in subjects with type 2 diabetes mellitus compared with incretin-based therapy
| العنوان: | Empagliflozin influences blood viscosity and wall shear stress in subjects with type 2 diabetes mellitus compared with incretin-based therapy |
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| المؤلفون: | Claudio Cortese, Faustina Scavelli, Concetta Irace, Agostino Gnasso, Antonio Cutruzzolà, Rosa Oliverio, Francesco Casciaro |
| المصدر: | Cardiovascular Diabetology Cardiovascular Diabetology, Vol 17, Iss 1, Pp 1-9 (2018) |
| بيانات النشر: | BioMed Central, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Male, lcsh:Diseases of the circulatory (Cardiovascular) system, Time Factors, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Blood viscosity, Empagliflozin, 030204 cardiovascular system & hematology, Carotid Intima-Media Thickness, 0302 clinical medicine, Glucosides, Medicine, Prospective Studies, Original Investigation, Middle Aged, Blood Viscosity, Metformin, Treatment Outcome, Sitagliptin, Cardiology, Female, Cardiology and Cardiovascular Medicine, Rheology, medicine.drug, medicine.medical_specialty, Carotid Artery, Common, Incretin, 030209 endocrinology & metabolism, Incretins, 03 medical and health sciences, Intima-plus media thickness, Internal medicine, Diabetes mellitus, Humans, Benzhydryl Compounds, Sodium-Glucose Transporter 2 Inhibitors, Aged, Shear stress, business.industry, Liraglutide, Insulin, Sitagliptin Phosphate, medicine.disease, Diabetes Mellitus, Type 2, lcsh:RC666-701, Regional Blood Flow, Stress, Mechanical, business |
| الوصف: | Background Cardiovascular protection following empagliflozin therapy is not entirely attributable to the glucose lowering effect. Increased hematocrit might influence the shear stress that is the main force acting on the endothelium, regulating its anti-atherogenic function. Objective We designed the study with the aim of investigating the effect of empagliflozin on blood viscosity and shear stress in the carotid arteries. A secondary endpoint was the effect of empagliflozin on carotid artery wall thickness. Methods The study was a non-randomized, open, prospective cohort study including 35 type 2 diabetic outpatients who were offered empagliflozin or incretin-based therapy (7 liraglutide, 8 sitagliptin) in combination with insulin and metformin. Blood viscosity, shear stress and carotid wall thickness were measured at baseline and at 1 and 3 months of treatment. Blood viscosity was measured with a viscometer, and shear stress was calculated using a validated formula. Intima-media thickness (IMT) of the carotid artery was detected by ultrasound and was measured with dedicated software. Results Blood viscosity (4.87 ± 0.57 vs 5.32 ± 0.66 cP, p |
| اللغة: | English |
| تدمد: | 1475-2840 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07782e25813776218c9a27f67da7f708Test http://europepmc.org/articles/PMC5891980Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....07782e25813776218c9a27f67da7f708 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14752840 |
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