Relationship between insulin resistance, coronary plaque, and clinical outcomes in patients with acute coronary syndromes: an analysis from the PROSPECT study
| العنوان: | Relationship between insulin resistance, coronary plaque, and clinical outcomes in patients with acute coronary syndromes: an analysis from the PROSPECT study |
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| المؤلفون: | Gary S. Mintz, Patrick W. Serruys, Björn Redfors, Roxana Mehran, Gennaro Giustino, Serdar Farhan, Gregg W. Stone, Bernard De Bruyne, Birgit Vogel, Akiko Maehara, Ori Ben-Yehuda, Thomas McAndrew |
| المصدر: | Cardiovascular Diabetology, Vol 20, Iss 1, Pp 1-10 (2021) Cardiovascular Diabetology |
| بيانات النشر: | BMC, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Acute coronary syndrome, lcsh:Diseases of the circulatory (Cardiovascular) system, Time Factors, Endocrinology, Diabetes and Metabolism, Coronary Artery Disease, Patient Readmission, Risk Assessment, Percutaneous Coronary Intervention, Insulin resistance, Risk Factors, Internal medicine, Diabetes mellitus, Intravascular ultrasound, Diabetes Mellitus, Prevalence, medicine, Clinical endpoint, Humans, Insulin, Culprit and non-culprit lesion events, Myocardial infarction, Ultrasonography, Interventional, Original Investigation, Aged, medicine.diagnostic_test, business.industry, Hazard ratio, Middle Aged, medicine.disease, Plaque, Atherosclerotic, United States, Europe, Treatment Outcome, Glucose, lcsh:RC666-701, Disease Progression, Female, Cardiology and Cardiovascular Medicine, business, Mace |
| الوصف: | Background We investigated the association of insulin resistance (IR) with coronary plaque morphology and the risk of cardiovascular events in patients enrolled in the Providing Regional Observations to Study Predictors of Events in Coronary Tree (PROSPECT) study. Methods Patients with acute coronary syndromes (ACS) were divided based on DM status. Non-DM patients were further stratified according to homeostasis-model-assessment IR (HOMA-IR) index as insulin sensitive (IS; HOMA-IR ≤ 2), likely-IR (LIR; 2 Results Among non-diabetic patients, 109 patients (21.5%) were categorized as LIR, and 65 patients (12.8%) as DIR. Patients with DIR or DM had significantly higher rates of echolucent plaque compared with LIR and IS. In addition, DIR and DM were independently associated with increased risk of MACE compared with IS (adjusted hazard ratio [aHR] 2.29, 95% confidence interval [CI] 1.22–4.29, p = 0.01 and aHR 2.12, 95% CI 1.19–3.75, p = 0.009, respectively). Conclusions IR is common among patients with ACS. DM and advanced but not early stages of IR are independently associated with increased risk of adverse cardiovascular events. Trial Registration ClinicalTrials.gov Identifier: NCT00180466. |
| اللغة: | English |
| تدمد: | 1475-2840 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2426f0ac370a0747406d547e160f3650Test https://doaj.org/article/df526e13098d4ef38349b0490ea468e7Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....2426f0ac370a0747406d547e160f3650 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14752840 |
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