Maximal exercise test is a useful method for physical capacity and oxygen consumption determination in streptozotocin-diabetic rats
| العنوان: | Maximal exercise test is a useful method for physical capacity and oxygen consumption determination in streptozotocin-diabetic rats |
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| المؤلفون: | Marcelo V. Heeren, Maria Claudia Irigoyen, Cristiano Mostarda, Kátia De Angelis, Diego Figueroa, Bruno Rodrigues |
| المصدر: | Cardiovascular Diabetology, Vol 6, Iss 1, p 38 (2007) Cardiovascular Diabetology |
| بيانات النشر: | BMC, 2007. |
| سنة النشر: | 2007 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, lcsh:Diseases of the circulatory (Cardiovascular) system, Future studies, Endocrinology, Diabetes and Metabolism, chemistry.chemical_element, Oxygen, Diabetes Mellitus, Experimental, Animal science, Oxygen Consumption, Internal medicine, Physical Conditioning, Animal, Linear regression, medicine, Gas analysis, Animals, Treadmill, Rats, Wistar, business.industry, Methodology, Reproducibility of Results, Exercise capacity, Streptozotocin, Rats, chemistry, Physical Fitness, lcsh:RC666-701, Physical therapy, Regression Analysis, Maximal exercise, Cardiology and Cardiovascular Medicine, business, human activities, medicine.drug |
| الوصف: | Background The aim of the present study was to investigate the relationship between speed during maximum exercise test (ET) and oxygen consumption (VO2) in control and STZ-diabetic rats, in order to provide a useful method to determine exercise capacity and prescription in researches involving STZ-diabetic rats. Methods Male Wistar rats were divided into two groups: control (CG, n = 10) and diabetic (DG, n = 8). The animals were submitted to ET on treadmill with simultaneous gas analysis through open respirometry system. ET and VO2 were assessed 60 days after diabetes induction (STZ, 50 mg/Kg). Results VO2 maximum was reduced in STZ-diabetic rats (72.5 ± 1 mL/Kg/min-1) compared to CG rats (81.1 ± 1 mL/Kg/min-1). There were positive correlations between ET speed and VO2 (r = 0.87 for CG and r = 0.8 for DG), as well as between ET speed and VO2 reserve (r = 0.77 for CG and r = 0.7 for DG). Positive correlations were also obtained between measured VO2 and VO2 predicted values (r = 0.81 for CG and r = 0.75 for DG) by linear regression equations to CG (VO2 = 1.54 * ET speed + 52.34) and DG (VO2 = 1.16 * ET speed + 51.99). Moreover, we observed that 60% of ET speed corresponded to 72 and 75% of VO2 reserve for CG and DG, respectively. The maximum ET speed was also correlated with VO2 maximum for both groups (CG: r = 0.7 and DG: r = 0.7). Conclusion These results suggest that: a) VO2 and VO2 reserve can be estimated using linear regression equations obtained from correlations with ET speed for each studied group; b) exercise training can be prescribed based on ET in control and diabetic-STZ rats; c) physical capacity can be determined by ET. Therefore, ET, which involves a relatively simple methodology and low cost, can be used as an indicator of cardio-respiratory capacity in future studies that investigate the physiological effect of acute or chronic exercise in control and STZ-diabetic male rats. |
| اللغة: | English |
| تدمد: | 1475-2840 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f627d76379e5d9a46ef57e71b366b36eTest http://www.cardiab.com/content/6/1/38Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....f627d76379e5d9a46ef57e71b366b36e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14752840 |
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