Association of the Phe206Leu Allele of the L-Selectin Gene with Coronary Artery Disease
| العنوان: | Association of the Phe206Leu Allele of the L-Selectin Gene with Coronary Artery Disease |
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| المؤلفون: | Ahmad Massoud, Nader Tajik, Mehrdad Hajilooi, Hossein Eftekhari, Arashmidos Sanati |
| المصدر: | Cardiology. 105:113-118 |
| بيانات النشر: | S. Karger AG, 2006. |
| سنة النشر: | 2006 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Phenylalanine, Mutation, Missense, Coronary Artery Disease, Iran, Bioinformatics, Coronary artery disease, Gene Frequency, Leucine, Polymorphism (computer science), Internal medicine, Humans, Medicine, Pharmacology (medical), L-Selectin, Allele, Gene, Aged, biology, business.industry, Middle Aged, medicine.disease, Case-Control Studies, Cardiology, biology.protein, Female, L-selectin, Cardiology and Cardiovascular Medicine, business |
| الوصف: | Background and Aims: The aim of this study was to assess the association between the L-selectin Phe206Leu polymorphism and coronary artery disease. Methods: A total of 322 patients (221 men and 101 women) with coronary artery disease in one or more vessels documented by angiography were studied; 157 subjects (85 men and 72 women) without atherosclerosis were included as controls. All subjects were genotyped for the L-selectin Phe206Leu gene polymorphism using polymerase chain reaction with sequence-specific primer (PCR-SSP). To assess disease severity, all patients were classified by numbers of coronary arteries with 50% stenosis. Results: A significantly increased frequency of the 206Leu mutant allele was observed in patients with coronary artery disease compared to the controls. The 206Leu allele frequency occurred in 42% of the patients with coronary artery disease compared to 30% of the controls (p < 0.009). No association was found between the severity of coronary artery disease and the L-selectin Phe206Leu polymorphism. Conclusion: Our findings suggest that carriage of L-selectin 206Leu mutant allele could contribute to susceptibility of Iranian individuals to contracting coronary artery disease. |
| تدمد: | 1421-9751 0008-6312 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25cf828a763a83b977140f38a124decaTest https://doi.org/10.1159/000090212Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....25cf828a763a83b977140f38a124deca |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14219751 00086312 |
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