التفاصيل البيبلوغرافية
| العنوان: |
Molecular profiles of benign and (pre)malignant endometrial lesions. |
| المؤلفون: |
van der Putten, Louis J. M., van Hoof, Renée, Tops, Bastiaan B. J., Snijders, Marc P. L. M., van den Berg-van Erp, Saskia H., van der Wurff, Anneke A. M., Bulten, Johan, Pijnenborg, Johanna M. A., Massuger, Leon F. A. G. |
| المصدر: |
Carcinogenesis; Mar2017, Vol. 38 Issue 3, p329-335, 7p |
| مصطلحات موضوعية: |
SINGLE molecules, CARCINOGENESIS, ENDOMETRIAL cancer, CARCINOMA, HYPERPLASIA |
| مستخلص: |
Endometrial carcinomas are histologically classified as endometrioid, assumed to originate from hyperplastic endometrium, or non-endometrioid carcinomas, assumed to originate from atrophic endometrium. However, both on a histological and a molecular level there are indications that there are more carcinoma types and carcinogenetic pathways. This study aims to analyze endometrial carcinogenesis on a molecular level. The presence of known KRAS, PIK3CA, AKT1, CTNNB1, BRAF, EGFR and NRAS mutations was studied in proliferative, atrophic and hyperplastic endometrium, endometrioid and serous carcinomas, and the endometrium next to these carcinomas, using single molecule Molecular Inversion Probes. Mutations were found in 9 (15%) of the 62 non atypical, and in 6 (18%) of the 34 atypical hyperplasia cases. In comparison, mutations were found in 1 (3%) of the simple, and 8 (30%) of the 27 complex hyperplasia cases. In 12/22 (55%) endometrioid carcinomas, a mutation was found. The KRAS gene was most often mutated in carcinomas next to hyperplastic endometrium, whereas PIK3CA and CTNNB1 mutations were found in endometrioid carcinomas with adjacent atrophic endometrium. Complex hyperplasia rather than atypical hyperplasia appears to be the most important lesion in the carcinogenesis of endometrioid carcinomas, and KRAS, PIK3CA and CTNNB1 mutations appear to play an important role in this process. Carcinogenesis of endometrioid carcinomas next to hyperplasia seems to be different to that of those next to atrophia. The value of these findings in managing endometrial hyperplasia and carcinoma should be studied. [ABSTRACT FROM AUTHOR] |
|
Copyright of Carcinogenesis is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
Full Text Finder