Pterostilbene inhibited tumor invasion via suppressing multiple signal transduction pathways in human hepatocellular carcinoma cells
| العنوان: | Pterostilbene inhibited tumor invasion via suppressing multiple signal transduction pathways in human hepatocellular carcinoma cells |
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| المؤلفون: | Min-Hsiung Pan, Ju Ming Wang, Chi-Tang Ho, Yi Siou Chiou, Vladimir Badmaev, Wei-Jen Chen |
| المصدر: | Carcinogenesis. 30:1234-1242 |
| بيانات النشر: | Oxford University Press (OUP), 2009. |
| سنة النشر: | 2009 |
| مصطلحات موضوعية: | Cancer Research, Carcinoma, Hepatocellular, Lung Neoplasms, Pterostilbene, Transplantation, Heterologous, Antineoplastic Agents, Biology, p38 Mitogen-Activated Protein Kinases, Mice, Phosphatidylinositol 3-Kinases, chemistry.chemical_compound, Cell Movement, Epidermal growth factor, Stilbenes, Animals, Humans, Neoplasm Invasiveness, Protein kinase A, Protein kinase B, Protein kinase C, Mitogen-Activated Protein Kinase 3, Liver Neoplasms, JNK Mitogen-Activated Protein Kinases, NF-kappa B, General Medicine, Gene Expression Regulation, Neoplastic, Transcription Factor AP-1, Vascular endothelial growth factor A, Matrix Metalloproteinase 9, chemistry, Cancer cell, Cancer research, Tetradecanoylphorbol Acetate, Signal transduction, Neoplasm Transplantation, Signal Transduction |
| الوصف: | Pterostilbene, a natural dimethylated analog of resveratrol, is known to have diverse pharmacologic activities including anticancer, anti-inflammation, antioxidant, apoptosis, anti-proliferation and analgesic potential. However, the effects of pterostilbene in preventing invasion of cancer cells have not been studied. Here, we report our finding that pterostilbene significantly suppressed 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced invasion, migration and metastasis of human hepatoma cells (HepG(2) cells). Increase in the enzyme activity, protein and messenger RNA levels of matrix metalloproteinase (MMP)-9 were observed in TPA-treated HepG(2) cells, and these were blocked by pterostilbene. In addition, pterostilbene can inhibit TPA-induced expression of vascular endothelial growth factor, epidermal growth factor and epidermal growth factor receptor. Transient transfection experiments also showed that pterostilbene strongly inhibited TPA-stimulated nuclear factor kappa B (NF-kappaB) and activator protein-1 (AP-1)-dependent transcriptional activity in HepG(2) cells. Moreover, pterostilbene can suppress TPA-induced activation of extracellular signal-regulated kinase 1/2, p38 mitogen-activated protein kinase, c-Jun N-terminal kinases 1/2 and phosphatidylinositol 3-kinase/Akt and protein kinase C that are upstream of NF-kappaB and AP-1. Significant therapeutic effects were further demonstrated in vivo by treating nude mice with pterostilbene (50 and 250 mg/kg intraperitoneally) after inoculation with HepG(2) cells into the tail vein. Presented data reveal that pterostilbene is a novel, effective, anti-metastatic agent that functions by downregulating MMP-9 gene expression. |
| تدمد: | 1460-2180 0143-3334 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::174837b5d74c00624b2b07c4841b95c6Test https://doi.org/10.1093/carcin/bgp121Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....174837b5d74c00624b2b07c4841b95c6 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14602180 01433334 |
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