دورية أكاديمية
Does 5-ALA Fluorescence Microscopy Improve Complete Resectability in Cerebral/Cerebellar Metastatic Surgery? A Retrospective Data Analysis from a Cranial Center.
| العنوان: | Does 5-ALA Fluorescence Microscopy Improve Complete Resectability in Cerebral/Cerebellar Metastatic Surgery? A Retrospective Data Analysis from a Cranial Center. |
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| المؤلفون: | Sarkis, Hraq Mourad, Zawy Alsofy, Samer, Stroop, Ralf, Lewitz, Marc, Schipmann, Stephanie, Unnewehr, Markus, Paulus, Werner, Nakamura, Makoto, Ewelt, Christian |
| المصدر: | Cancers (Basel) ; ISSN:2072-6694 ; Volume:16 ; Issue:12 |
| بيانات النشر: | MDPI |
| سنة النشر: | 2024 |
| المجموعة: | PubMed Central (PMC) |
| مصطلحات موضوعية: | 5-aminolevulinic acid (5-ALA), fluorescence, malignant gliomas, metastatic brain tumors, protoporphyrin IX |
| الوصف: | (1) Background: In this study, the intraoperative fluorescence behavior of brain metastases after the administration of 5-aminolevulinic acid (5-ALA) was analyzed. The aim was to investigate whether the resection of brain metastases using 5-ALA fluorescence also leads to a more complete resections and thus to a prolongation of survival; (2) Methods: The following variables have been considered: age, sex, number of metastases, localization, involvement of eloquent area, correlation between fluorescence and primary tumor/subtype, resection, and survival time. The influence on the degree of resection was determined with a control MRI within the first three postoperative days; (3) Results: Brain metastases fluoresced in 57.5% of cases. The highest fluorescence rates of 73.3% were found in breast carcinoma metastases and the histologic subtype adenocarcinoma (68.1%). No correlation between fluorescence behavior and localization, primary tumor, or histological subtype was found. Complete resection was detected in 82.5%, of which 56.1% were fluorescence positive. There was a trend towards improved resectability (increase of 12.1%) and a significantly longer survival time (p = 0.009) in the fluorescence-positive group; (4) Conclusions: 5-ALA-assisted extirpation leads to a more complete resection and longer survival and can therefore represent a low-risk addition to modern surgery for brain metastases. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://doi.org/10.3390/cancers16122242Test; https://pubmed.ncbi.nlm.nih.gov/38927947Test; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11201798Test/ |
| DOI: | 10.3390/cancers16122242 |
| الإتاحة: | https://doi.org/10.3390/cancers16122242Test https://pubmed.ncbi.nlm.nih.gov/38927947Test https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11201798Test/ |
| رقم الانضمام: | edsbas.C9B075B9 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/cancers16122242 |
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