Head and Body/Tail Pancreatic Carcinomas Are Not the Same Tumors
| العنوان: | Head and Body/Tail Pancreatic Carcinomas Are Not the Same Tumors |
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| المؤلفون: | Aoki, Shuichi, Inoue, Koetsu, Klein, Sebastian, Halvorsen, Stefan, Chen, Jiang, Matsui, Aya, Nikmaneshi, Mohammad, Kitahara, Shuji, Hato, Tai, Chen, Xianfeng, Kawakubo, Kazumichi, Nia, Hadi, Chen, Ivy, Schanne, Daniel, Shigeta, Kohei, Kikuchi, Hiroto, Ramjiawan, Rakesh, Schmidt, Tyge Ce, Iwasaki, Masaaki, Yau, Thomas, Hong, Theodore, Quaas, Alexander, Plum, Patrick, Dima, Simona, Popescu, Irinel, Bardeesy, Nabeel, Munn, Lance, Borad, Mitesh, Sassi, Slim, Jain, Rakesh, Zhu, Andrew, Duda, Dan, Guo, Yuchen, Gabola, Monica, Lattanzio, Rossano, Paul, Conception, Pinet, Valérie, Tang, Ruizhi, Turali, Hulya, Bremond, Julie, Longobardi, Ciro, Maurizy, Chloé, da Costa, Quentin, Finetti, Pascal, Boissière-Michot, Florence, Rivière, Benjamin, Lemmers, Céline, Garnier, Séverine, Bertucci, François, Zlobec, Inti, Chebli, Karim, Tazi, Jamal, Azar, Rania, Blanchard, Jean-Marie, Sicinski, Peter, Lemmers, Bénédicte, Hahne, Michael, Gonçalves, Anthony, Guille, Arnaud, Adelaïde, José, Carbuccia, Nadine, Billon, Emilien, Sfumato, Patrick, Monneur, Audrey, Pécheux, Christophe, Khran, Martin, Brunelle, Serge, Mescam, Lenaïg, Thomassin-Piana, Jeanne, Poizat, Flora, Charafe-Jauffret, Emmanuelle, Turrini, Olivier, Lambaudie, Eric, Provansal, Magali, Extra, Jean-Marc, Madroszyk, Anne, Gilabert, Marine, Sabatier, Renaud, Vicier, Cécile, Chabannon, Christian, Pakradouni, Jihane, Viens, Patrice, André, Fabrice, Gravis, Gwenaelle, Popovici, Cornel, Birnbaum, Daniel, Chaffanet, Max, Amoozgar, Zohreh, Kloepper, Jonas, Ren, Jun, Tay, Rong En, Kazer, Samuel, Kiner, Evgeny, Krishnan, Shanmugarajan, Posada, Jessica, Ghosh, Mitrajit, Wong, Christina, Ferraro, Gino, Batista, Ana, Wang, Nancy, Badeaux, Mark, Roberge, Sylvie, Xu, Lei, Huang, Peigen, Shalek, Alex, Fukumura, Dai, Kim, Hye-Jung, Shigeta, Ayako, Staiculescu, Daniel, Zopf, Dieter, Fiebig, Lukas, Hobbs, Gabriela, Cobbold, Mark, Goyal, Lipika, Birnbaum, David, Mamessier, Emilie |
| المساهمون: | Centre de Recherche en Cancérologie de Marseille (CRCM), Aix Marseille Université (AMU)-Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS) |
| المصدر: | Cancers Cancers, 2019, 11 (4), pp.497. ⟨10.3390/cancers11040497⟩ Volume 11 Issue 4 Cancers, Vol 11, Iss 4, p 497 (2019) |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Cancer Research, Pancreatic ductal adenocarcinoma, endocrine system diseases, pancreatic cancer, [SDV.CAN]Life Sciences [q-bio]/Cancer, Biology, lcsh:RC254-282, survival, Article, 03 medical and health sciences, 0302 clinical medicine, Downregulation and upregulation, Pancreatic cancer, Gene expression, medicine, Gene, tumor location, [SDV.IMM.IMM]Life Sciences [q-bio]/Immunology/Immunotherapy, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, medicine.disease, Phenotype, digestive system diseases, Gene expression profiling, medicine.anatomical_structure, Oncology, expression profiling, 030220 oncology & carcinogenesis, Cancer research, 030211 gastroenterology & hepatology, prognosis, Pancreas |
| الوصف: | The association between pancreatic ductal adenocarcinoma (PDAC) location (head vs. Body/Tail (B/T)) and clinical outcome remains controversial. We collected clinicopathological and gene expression data from 249 resected PDAC samples from public data sets, and we compared data between 208 head and 41 B/T samples. The 2-year overall survival (OS) was better for the head than for the B/T PDACs (44 vs. 27%, p = 0.043), especially when comparing tumors with similar TNM classification (T3/4N0M0: 67% vs. 17%, p = 0.002) or from the same molecular class (squamous subtype: 31% vs. 0%, p < 0.0001). Bailey&rsquo s molecular subtypes were differentially distributed within the two groups, with the immunogenic subtype being underrepresented in the &ldquo B/T&rdquo group (p = 0.005). Uni- and multivariate analyses indicated that PDAC anatomic location was an independent prognostic factor. Finally, the supervised analysis identified 334 genes differentially expressed. Genes upregulated in the &ldquo head&rdquo group suggested lymphocyte activation and pancreas exocrine functions. Genes upregulated in the &ldquo group were related to keratinocyte differentiation, in line with the enrichment for squamous phenotype. We identified a robust gene expression signature (GES) associated with B/T PDAC location, suggesting that head and B/T PDAC are different. This GES could serve as an indicator for differential therapeutic management based on PDAC location. |
| وصف الملف: | application/pdf |
| تدمد: | 2072-6694 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::676f0572987ae4f9827a064511125a13Test https://pubmed.ncbi.nlm.nih.gov/30965637Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....676f0572987ae4f9827a064511125a13 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20726694 |
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