المؤلفون: Raymon H. Grogan, Elliot J. Mitmaker, Orlo H. Clark

المصدر: Cancers, Vol 2, Iss 2, Pp 885-912 (2010)

مصطلحات موضوعية: thyroid cancer, biomarker, biological marker, molecular marker, tumor marker, molecular pathways, epigenetics, serum based biomarkers, genomics, proteomics, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

الوصف: Thyroid cancer is the most common malignancy of the endocrine system. The diagnosis of thyroid nodules, made by neck examination and ultrasonography, is a common event occurring in over 50% of the patient population over the age of 50. Yet, only 5% of these patients will be diagnosed with cancer. Fine needle aspiration biopsy is the gold standard for diagnosing thyroid nodules. However, 10–15% of these biopsies are inconclusive, ultimately requiring a diagnostic thyroid lobectomy. Consequently, research in thyroid biomarkers has become an area of active interest. In the 40 years since calcitonin was first described as the biomarker for medullary thyroid cancer, new biomarkers in thyroid cancer have been discovered. Advances in genomic and proteomic technologies have defined many of these novel thyroid biomarkers. The purpose of this article is to provide a comprehensive literature review of how these biomarkers have evolved from simple screening tests into a complex array of multiple markers to help predict the malignant potential and genetic signature of thyroid neoplasms.

وصف الملف: electronic resource

العلاقة: http://www.mdpi.com/2072-6694/2/2/885Test/; https://doaj.org/toc/2072-6694Test

الوصول الحر: https://doaj.org/article/a165b5ee6430471185d486fab7bb3c22Test

المؤلفون: Orlo H. Clark, Raymon H. Grogan, Elliot J. Mitmaker

المصدر: Cancers, Vol 2, Iss 2, Pp 885-912 (2010)
Cancers

مصطلحات موضوعية: Thyroid nodules, Cancer Research, endocrine system, endocrine system diseases, serum based biomarkers, Thyroid Lobectomy, Review, Bioinformatics, lcsh:RC254-282, proteomics, medicine, thyroid cancer, genomics, Thyroid cancer, Mass screening, Tumor marker, molecular marker, epigenetics, business.industry, Thyroid, Cancer, Medullary thyroid cancer, medicine.disease, biological marker, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, medicine.anatomical_structure, Oncology, tumor marker, biomarker, business, molecular pathways

الوصف: Thyroid cancer is the most common malignancy of the endocrine system. The diagnosis of thyroid nodules, made by neck examination and ultrasonography, is a common event occurring in over 50% of the patient population over the age of 50. Yet, only 5% of these patients will be diagnosed with cancer. Fine needle aspiration biopsy is the gold standard for diagnosing thyroid nodules. However, 10-15% of these biopsies are inconclusive, ultimately requiring a diagnostic thyroid lobectomy. Consequently, research in thyroid biomarkers has become an area of active interest. In the 40 years since calcitonin was first described as the biomarker for medullary thyroid cancer, new biomarkers in thyroid cancer have been discovered. Advances in genomic and proteomic technologies have defined many of these novel thyroid biomarkers. The purpose of this article is to provide a comprehensive literature review of how these biomarkers have evolved from simple screening tests into a complex array of multiple markers to help predict the malignant potential and genetic signature of thyroid neoplasms.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9ac6d89ea42ef3e34d6fd8ae77dd694Test
http://www.mdpi.com/2072-6694/2/2/885Test/