دورية أكاديمية
Gene-environment interactions relevant to estrogen and risk of breast cancer: can gene-environment interactions be detected only among candidate SNPs from genome-wide association studies?
| العنوان: | Gene-environment interactions relevant to estrogen and risk of breast cancer: can gene-environment interactions be detected only among candidate SNPs from genome-wide association studies? |
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| المؤلفون: | Park, J., Choi, J.Y., Choi, J., Chung, S., Song, N., Park, S.K., Han, W., Noh, D.Y., Ahn, S.H., Lee, J.W., Kim, M.K., Jee, S.H., Wen, W.Q., Bolla, M.K., Wang, Q., Dennis, J., Michailidou, K., Shah, M.T., Conroy, D.M., Harrington, P.A., Mayes, R., Czene, K., Hall, P., Teras, L.R., Patel, A.V., Couch, F.J., Olson, J.E., Sawyer, E.J., Roylance, R., Bojesen, S.E., Flyger, H., Lambrechts, D., Baten, A., Matsuo, K., Ito, H., Guenel, P., Truong, T., Keeman, R., Schmidt, M.K., Wu, A.N.H., Tseng, C.C., Cox, A., Cross, S.S., Andrulis, I.L., Hopper, J.L., Southey, M.C., Wu, P.E., Shen, C.Y., Fasching, P.A., Ekici, A.B., Muir, K., Lophatananon, A., Brenner, H., Arndt, V., Jones, M.E., Swerdlow, A.J., Hoppe, R., Ko, Y.D., Hartman, M., Li, J.M., Mannermaa, A., Hartikainen, J.M., Benitez, J., Gonzalez-Neira, A., Haiman, C.A., Dork, T., Bogdanova, N.V., Teo, S.H., Taib, N.A.M., Fletcher, O., Johnson, N., Grip, M., Winqvist, R., Blomqvist, C., Nevanlinna, H., Lindblom, A., Wendt, C., Kristensen, V.N., Tollenaar, R.A.E.M., Heemskerk-Gerritsen, B.A.M., Radice, P., Bonanni, B., Hamann, U., Manoochehri, M., Lacey, J.V., Martinez, M.E., Dunning, A.M., Pharoah, P.D.P., Easton, D.F., Yoo, K.Y., Kang, D., KConFab Investigators, NBCS Collaborators |
| المصدر: | Cancers |
| سنة النشر: | 2021 |
| المجموعة: | Leiden Repository (Leiden University) |
| مصطلحات موضوعية: | breast cancer, estrogen, gene-environment interaction |
| الوصف: | Simple Summary Breast cancer is the most common cancer in females worldwide. To date, many gene-environment interaction (GxE) studies have been conducted to better understand how genetic factors combine with environmental factors to influence risk. However, previous studies have not found or found only a few interactions by using SNPs which were discovered from genome-wide association studies and have been conducted, for the most part, within European populations. In this study, we focused on estrogen-related lifestyle factors that have been identified for breast cancer, including several well-established reproductive factors that are mediated by hormonal mechanisms. We aimed to examine whether there are any gene and environmental factor interactions related to estrogen exposure or metabolism using a candidate approach in Korean women. We found two interactions in this study, although they were not replicated in the independent large consortium data. These findings suggest specificity in Koreans for breast cancer risk.In this study we aim to examine gene-environment interactions (GxEs) between genes involved with estrogen metabolism and environmental factors related to estrogen exposure. GxE analyses were conducted with 1970 Korean breast cancer cases and 2052 controls in the case-control study, the Seoul Breast Cancer Study (SEBCS). A total of 11,555 SNPs from the 137 candidate genes were included in the GxE analyses with eight established environmental factors. A replication test was conducted by using an independent population from the Breast Cancer Association Consortium (BCAC), with 62,485 Europeans and 9047 Asians. The GxE tests were performed by using two-step methods in GxEScan software. Two interactions were found in the SEBCS. The first interaction was shown between rs13035764 of NCOA1 and age at menarche in the GE|2df model (p-2df = 1.2 x 10(-3)). The age at menarche before 14 years old was associated with the high risk of breast cancer, and the risk was higher when subjects had homozygous minor ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | https://www.mdpi.com/2072-6694/13/10/2370/pdfTest; lumc-id: 168662399; https://hdl.handle.net/1887/3279856Test |
| DOI: | 10.3390/cancers13102370 |
| الإتاحة: | https://doi.org/10.3390/cancers13102370Test https://hdl.handle.net/1887/3279856Test https://www.mdpi.com/2072-6694/13/10/2370/pdfTest |
| رقم الانضمام: | edsbas.C318AD30 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/cancers13102370 |
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