Intra-Tumour Heterogeneity Is One of the Main Sources of Inter-Observer Variation in Scoring Stromal Tumour Infiltrating Lymphocytes in Triple Negative Breast Cancer
| العنوان: | Intra-Tumour Heterogeneity Is One of the Main Sources of Inter-Observer Variation in Scoring Stromal Tumour Infiltrating Lymphocytes in Triple Negative Breast Cancer |
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| المؤلفون: | Elena Provenzano, Päivi Heikkilä, Elisabeth Specht Stovgaard, Gábor Cserni, Sharon A. Glynn, Inta Liepniece-Karele, Simonetta Bianchi, Xavier Andreu, Janina Kulka, Mark O’Loughlin, Caterina Marchiò, Davood Roshan, Maria Pia Foschini, Mark Webber, Zsuzsanna Bago-Horvath, Anna Sapino, Grace Callagy, Peter Regitnig, Giuseppe Floris, Ewa Chmielik, Ales Ryska, Anikó Kovács, Cecily Quinn, Angelika Reiner, Vasiliki Zolota, Darren Kilmartin, Anne Vibeke Lænkholm, Paulo Figueiredo |
| المساهمون: | Bianchi, Simonetta [0000-0002-2605-4758], Marchiò, Caterina [0000-0003-2024-6131], Specht Stovgaard, Elisabeth [0000-0002-5784-3610], Glynn, Sharon A. [0000-0003-1459-2580], Apollo - University of Cambridge Repository, HUSLAB, Department of Pathology, Kilmartin D., O'Loughlin M., Andreu X., Bago-Horvath Z., Bianchi S., Chmielik E., Cserni G., Figueiredo P., Floris G., Foschini M.P., Kovacs A., Heikkila P., Kulka J., Laenkholm A.-V., Liepniece-Karele I., Marchio C., Provenzano E., Regitnig P., Reiner A., Ryska A., Sapino A., Stovgaard E.S., Quinn C., Zolota V., Webber M., Roshan D., Glynn S.A., Callagy G., Cserni, Gábor [0000-0003-1344-7744], Foschini, Maria Pia [0000-0001-7079-7260], Regitnig, Peter [0000-0002-1371-1595], Sapino, Anna [0000-0003-3542-9571], Roshan, Davood [0000-0002-6553-640X], Glynn, Sharon A [0000-0003-1459-2580] |
| المصدر: | Cancers Volume 13 Issue 17 Kilmartin, D, O’Loughlin, M, Andreu, X, Bagó-Horváth, Z, Bianchi, S, Chmielik, E, Cserni, G, Figueiredo, P, Floris, G, Foschini, M P, Kovács, A, Heikkilä, P, Kulka, J, Laenkholm, A V, Liepniece-Karele, I, Marchiò, C, Provenzano, E, Regitnig, P, Reiner, A, Ryška, A, Sapino, A, Stovgaard, E S, Quinn, C, Zolota, V, Webber, M, Roshan, D, Glynn, S A & Callagy, G 2021, ' Intra-tumour heterogeneity is one of the main sources of inter-observer variation in scoring stromal tumour infiltrating lymphocytes in triple negative breast cancer ', Cancers, vol. 13, no. 17, 4410 . https://doi.org/10.3390/cancers13174410Test Cancers, Vol 13, Iss 4410, p 4410 (2021) |
| بيانات النشر: | Multidisciplinary Digital Publishing Institute, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Cancer Research, medicine.medical_specialty, Tumour heterogeneity, 3122 Cancers, Routine practice, sTILs, Article, triple negative, 03 medical and health sciences, 0302 clinical medicine, Breast cancer, breast cancer, RESIDUAL DISEASE, medicine, TILs, Triple negative, reproducibility, RC254-282, Triple-negative breast cancer, 030304 developmental biology, 0303 health sciences, Reproducibility, Science & Technology, business.industry, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, TIL, CHEMOTHERAPY, medicine.disease, PREDICTIVE-VALUE, Predictive value, 3. Good health, International immuno-oncology biomarker working group, STILs, PROGNOSTIC VALUE, Oncology, STIL, 030220 oncology & carcinogenesis, AGREEMENT, international immuno-oncology biomarker working group, TRIAL, Radiology, business, Observer variation, TILS, Life Sciences & Biomedicine |
| الوصف: | Stromal tumour infiltrating lymphocytes (sTILs) are a strong prognostic marker in triple negative breast cancer (TNBC). Consistency scoring sTILs is good and was excellent when an internet-based scoring aid developed by the TIL-WG was used to score cases in a reproducibility study. This study aimed to evaluate the reproducibility of sTILs assessment using this scoring aid in cases from routine practice and to explore the potential of the tool to overcome variability in scoring. Twenty-three breast pathologists scored sTILs in digitized slides of 49 TNBC biopsies using the scoring aid. Subsequently, fields of view (FOV) from each case were selected by one pathologist and scored by the group using the tool. Inter-observer agreement was good for absolute sTILs (ICC 0.634, 95% CI 0.539–0.735, p < 0.001) but was poor to fair using binary cutpoints. sTILs heterogeneity was the main contributor to disagreement. When pathologists scored the same FOV from each case, inter-observer agreement was excellent for absolute sTILs (ICC 0.798, 95% CI 0.727–0.864, p < 0.001) and good for the 20% (ICC 0.657, 95% CI 0.561–0.756, p < 0.001) and 40% (ICC 0.644, 95% CI 0.546–0.745, p < 0.001) cutpoints. However, there was a wide range of scores for many cases. Reproducibility scoring sTILs is good when the scoring aid is used. Heterogeneity is the main contributor to variance and will need to be overcome for analytic validity to be achieved. |
| وصف الملف: | application/pdf; Electronic; application/zip; text/xml; ELETTRONICO |
| اللغة: | English |
| تدمد: | 2072-6694 |
| DOI: | 10.3390/cancers13174410 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b656e320553d604f0ec614e8ebe41cdTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....4b656e320553d604f0ec614e8ebe41cd |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20726694 |
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| DOI: | 10.3390/cancers13174410 |