التفاصيل البيبلوغرافية
العنوان:
Role of gene methylation in antitumor immune response: implication for tumor progression
المؤلفون:
Maximino Redondo , A. Serrano , Isabel Castro-Vega
المساهمون:
[Serrano Garballo,A, Castro Vega,I] Department of Immunology, Hospital Universitario Virgen de la Victoria, Málaga, Spain. [Redondo,M] Department of Biochemistry, CIBER ESP, Hospital Costa del Sol Marbella, Málaga, Spain., This work was partially supported by Fondo de Investigaciones Sanitarias (FIS 09/910, Spain)
المصدر:
Cancers
سنة النشر:
2010
مصطلحات موضوعية:
Anatomy::Cells::Cells, Cultured::Cell Line::Cell Line, Tumor [Medical Subject Headings] , Cancer Research , Diseases::Neoplasms::Neoplasms by Site::Hematologic Neoplasms [Medical Subject Headings] , clusterin , ADN , Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Neoplasm Proteins::Melanoma-Specific Antigens::MART-1 Antigen [Medical Subject Headings] , Review , Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Hydrolases::Acid Anhydride Hydrolases::GTP Phosphohydrolases::GTP-Binding Proteins::Monomeric GTP-Binding Proteins::ras Proteins [Medical Subject Headings] , Inhibidores de Histona Desacetilasas , Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Carrier Proteins::Membrane Transport Proteins::ATP-Binding Cassette Transporters [Medical Subject Headings] , Chemicals and Drugs::Organic Chemicals::Amines::Hydroxylamines::Hydroxamic Acids [Medical Subject Headings] , Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Transferases::Phosphotransferases::Phosphotransferases (Alcohol Group Acceptor)::Protein Kinases::Protein-Serine-Threonine Kinases::Mitogen-Activated Protein Kinases [Medical Subject Headings] , Proteínas ras , Chemicals and Drugs::Organic Chemicals::Aza Compounds::Azacitidine [Medical Subject Headings] , Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Peptides::Intracellular Signaling Peptides and Proteins::Cyclin-Dependent Kinase Inhibitor Proteins::Cyclin-Dependent Kinase Inhibitor p16 [Medical Subject Headings] , Methylation , lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens , Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Glycoproteins::Clusterin [Medical Subject Headings] , Immunosurveillance , HLA , Ácidos Hidroxámicos , Azacitidina , Oncology , Proteínas Quinasas Mitógeno Activadas , Phenomena and Processes::Chemical Phenomena::Biochemical Phenomena::Biochemical Processes::DNA Methylation [Medical Subject Headings] , DNA methylation , Chemicals and Drugs::Biological Factors::Antigens::Antigens, Surface::Histocompatibility Antigens::HLA Antigens [Medical Subject Headings] , Interleucina-10 , Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Molecular Mechanisms of Pharmacological Action::Enzyme Inhibitors::Histone Deacetylase Inhibitors [Medical Subject Headings] , Metilación de ADN , Neoplasias Hematológicas , tumor , Phenomena and Processes::Immune System Phenomena::Immune System Processes::Tumor Escape [Medical Subject Headings] , Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Carrier Proteins [Medical Subject Headings] , Human leukocyte antigen , Citidina , Biology , lcsh:RC254-282 , Enfermedades Gastrointestinales , Chemicals and Drugs::Heterocyclic Compounds::Heterocyclic Compounds, 2-Ring::Indoles::Tryptamines::Dihydroxytryptamines::5,6-Dihydroxytryptamine [Medical Subject Headings] , Immune system , Antigen , Clusterina , Antígeno MART-1 , Epigenetics , Transportadoras de Casetes de Unión a ATP , Escape del Tumor , methylation , 5,6-Dihidroxitriptamina , Proteínas Portadoras , Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Membrane Proteins::Receptors, Cell Surface::Receptors, Immunologic::Receptors, Natural Killer Cell::Receptors, NK Cell Lectin-Like::NK Cell Lectin-Like Receptor Subfamily K [Medical Subject Headings] , Diseases::Digestive System Diseases::Gastrointestinal Diseases [Medical Subject Headings] , Inhibidor p16 de la Quinasa Dependiente de Ciclina , Antígenos HLA , Chemicals and Drugs::Heterocyclic Compounds::Heterocyclic Compounds, 1-Ring::Pyrimidines::Pyrimidine Nucleosides::Cytidine [Medical Subject Headings] , Línea Celular Tumoral , Tumor progression , Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Peptides::Intercellular Signaling Peptides and Proteins::Cytokines::Interleukins::Interleukin-10 [Medical Subject Headings] , Immunology , Cancer research , Metilasas de Modificación del ADN , Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Transferases::One-Carbon Group Transferases::Methyltransferases::DNA Modification Methylases [Medical Subject Headings] , Chemicals and Drugs::Nucleic Acids, Nucleotides, and Nucleosides::Nucleic Acids::DNA [Medical Subject Headings] , Subfamilia K de Receptores Similares a Lectina de Células NK
الوصف:
Cancer immunosurveillance theory has emphasized the role of escape mechanisms in tumor growth. In this respect, a very important factor is the molecular characterization of the mechanisms by which tumor cells evade immune recognition and destruction. Among the many escape mechanisms identified, alterations in classical and non-classical HLA (Human Leucocyte Antigens) class I and class II expression by tumor cells are of particular interest. In addition to the importance of HLA molecules, tumor-associated antigens and accessory/co-stimulatory molecules are also involved in immune recognition. The loss of HLA class I antigen expression and of co-stimulatory molecules can occur at genetic, transcriptional and post-transcriptional levels. Epigenetic defects are involved in at least some mechanisms that preclude mounting a successful host-antitumor response involving the HLA system, tumor-associated antigens, and accessory/co-stimulatory molecules. This review summarizes our current understanding of the role of methylation in the regulation of molecules involved in the tumor immune response. Yes
وصف الملف:
application/pdf
تدمد:
2072-6694
الوصول الحر:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1db7f18a86a9d808132ede7c4a47c1a5Test https://pubmed.ncbi.nlm.nih.gov/24212778Test
حقوق:
OPEN
رقم الانضمام:
edsair.doi.dedup.....1db7f18a86a9d808132ede7c4a47c1a5
قاعدة البيانات:
OpenAIRE
