The Evolution of Biomarkers in Thyroid Cancer—From Mass Screening to a Personalized Biosignature
| العنوان: | The Evolution of Biomarkers in Thyroid Cancer—From Mass Screening to a Personalized Biosignature |
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| المؤلفون: | Orlo H. Clark, Raymon H. Grogan, Elliot J. Mitmaker |
| المصدر: | Cancers, Vol 2, Iss 2, Pp 885-912 (2010) Cancers |
| بيانات النشر: | MDPI AG, 2010. |
| سنة النشر: | 2010 |
| مصطلحات موضوعية: | Thyroid nodules, Cancer Research, endocrine system, endocrine system diseases, serum based biomarkers, Thyroid Lobectomy, Review, Bioinformatics, lcsh:RC254-282, proteomics, medicine, thyroid cancer, genomics, Thyroid cancer, Mass screening, Tumor marker, molecular marker, epigenetics, business.industry, Thyroid, Cancer, Medullary thyroid cancer, medicine.disease, biological marker, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, medicine.anatomical_structure, Oncology, tumor marker, biomarker, business, molecular pathways |
| الوصف: | Thyroid cancer is the most common malignancy of the endocrine system. The diagnosis of thyroid nodules, made by neck examination and ultrasonography, is a common event occurring in over 50% of the patient population over the age of 50. Yet, only 5% of these patients will be diagnosed with cancer. Fine needle aspiration biopsy is the gold standard for diagnosing thyroid nodules. However, 10-15% of these biopsies are inconclusive, ultimately requiring a diagnostic thyroid lobectomy. Consequently, research in thyroid biomarkers has become an area of active interest. In the 40 years since calcitonin was first described as the biomarker for medullary thyroid cancer, new biomarkers in thyroid cancer have been discovered. Advances in genomic and proteomic technologies have defined many of these novel thyroid biomarkers. The purpose of this article is to provide a comprehensive literature review of how these biomarkers have evolved from simple screening tests into a complex array of multiple markers to help predict the malignant potential and genetic signature of thyroid neoplasms. |
| اللغة: | English |
| تدمد: | 2072-6694 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9ac6d89ea42ef3e34d6fd8ae77dd694Test http://www.mdpi.com/2072-6694/2/2/885Test/ |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....d9ac6d89ea42ef3e34d6fd8ae77dd694 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20726694 |
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