التفاصيل البيبلوغرافية
| العنوان: |
Impact of Change in Body Composition during Follow-Up on the Survival of GEP-NET. |
| المؤلفون: |
Sebastian-Valles, Fernando, Sánchez de la Blanca Carrero, Nuria, Rodríguez-Laval, Víctor, Martinez-Hernández, Rebeca, Serrano-Somavilla, Ana, Knott-Torcal, Carolina, Muñoz de Nova, José Luis, Martín-Pérez, Elena, Marazuela, Mónica, Sampedro-Nuñez, Miguel Antonio |
| المصدر: |
Cancers; Nov2022, Vol. 14 Issue 21, p5189, 16p |
| مصطلحات موضوعية: |
MORTALITY risk factors, PANCREATIC tumors, BODY composition, ALBUMINS, SKELETAL muscle, UREA, ANTHROPOMETRY, LEAN body mass, AGE distribution, METASTASIS, GASTROINTESTINAL tumors, CANCER patients, RISK assessment, NEUROENDOCRINE tumors, SURVIVAL analysis (Biometry), LACTATE dehydrogenase, COMPUTED tomography, TUMOR markers |
| مستخلص: |
Simple Summary: Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are heterogeneous rare diseases causing malnutrition and cachexia in which the study of body composition may have an impact in prognosis. In this context, we aimed to evaluate muscle and fat tissues by computed tomography (CT) at L3 level at diagnosis and at the end of follow-up in a cohort of 98 GET-NET patients and their relationships with clinical and biochemical variables as predictors of survival. Body composition measures and overall mortality correlated with age, ECOG, metastases, LDH, albumin and urea levels. Although there was no relationship between body composition variables at diagnosis and overall and specific mortality, an increase in low-density muscle and a decrease in normal-density muscle during follow-up were independently correlated to overall (p < 0.05) and tumor-cause mortality (p < 0.05). These results would suggest that nutritional status should therefore be supervised by specialists and an increase in good quality muscle could improve prognosis. Background: Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are heterogeneous rare diseases causing malnutrition and cachexia in which the study of body composition may have an impact in prognosis. Aim: Evaluation of muscle and fat tissues by computed tomography (CT) at the level of the third lumbar (L3 level) at diagnosis and at the end of follow-up in GET-NET patients and their relationships with clinical and biochemical variables as predictors of survival. Methodology: Ninety-eight GEP-NET patients were included. Clinical and biochemical parameters were evaluated. Total body, subcutaneous, visceral and total fat areas and very low-density, low-density, normal density, high-density, very high-density and total muscle areas were obtained from CT images. Results: Body composition measures and overall mortality correlated with age, ECOG (Eastern Cooperative Oncology Group performance status) metastases, lactate dehydrogenase (LDH), albumin and urea levels. Although there was no relationship between body composition variables at diagnosis and overall and specific mortality, an increase in low-density muscle and a decrease in normal-density muscle during follow-up were independently correlated to overall (p <0.05) and tumor-cause mortality (p < 0.05). Conclusion: Although body composition measures obtained by CT at diagnosis did not impact survival of GEP-NET patients, a loss of good quality muscle during follow-up was associated with an increased overall and tumor-related mortality. Nutritional status should therefore be supervised by nutrition specialists and an increase in good quality muscle could improve prognosis. [ABSTRACT FROM AUTHOR] |
|
Copyright of Cancers is the property of MDPI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
Full Text Finder