Upregulation of ZIP14 and Altered Zinc Homeostasis in Muscles in Pancreatic Cancer Cachexia
| العنوان: | Upregulation of ZIP14 and Altered Zinc Homeostasis in Muscles in Pancreatic Cancer Cachexia |
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| المؤلفون: | Stephanie Calluori, Anup K. Biswas, Sean Kim, Paul M. Grandgenett, Hanna Scholze, Courtney Coker, George Miller, Michael D. Kluger, Ahmad Rushdi Shakri, Kurenai Tanji, Wanchao Ma, Timothy James Zhong, Swarnali Acharyya, Thomas C. Caffrey, Matthias Szabolcs, Michael A. Hollingsworth |
| المصدر: | Cancers Volume 12 Issue 1 |
| بيانات النشر: | MDPI, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | 0301 basic medicine, muscle atrophy, Cancer Research, endocrine system diseases, zinc transporter, pancreatic cancer, pancreatic ductal adenocarcinoma, cachexia, Article, Cachexia, Metastasis, 03 medical and health sciences, 0302 clinical medicine, Breast cancer, Downregulation and upregulation, Pancreatic cancer, medicine, metastasis, zinc homeostasis, Wasting, Lung, business.industry, medicine.disease, Muscle atrophy, digestive system diseases, 3. Good health, Slc39a14, 030104 developmental biology, medicine.anatomical_structure, Oncology, 030220 oncology & carcinogenesis, Cancer research, medicine.symptom, business, ZIP14 |
| الوصف: | Pancreatic ductal adenocarcinoma (PDAC) is a lethal cancer type in which the mortality rate approaches the incidence rate. More than 85% of PDAC patients experience a profound loss of muscle mass and function, known as cachexia. PDAC patients with this condition suffer from decreased tolerance to anti-cancer therapies and often succumb to premature death due to respiratory and cardiac muscle wasting. Yet, there are no approved therapies available to alleviate cachexia. We previously found that upregulation of the metal ion transporter, Zip14, and altered zinc homeostasis are critical mediators of cachexia in metastatic colon, lung, and breast cancer models. Here, we show that a similar mechanism is likely driving the development of cachexia in PDAC. In two independent experimental metastasis models generated from the murine PDAC cell lines, Pan02 and FC1242, we observed aberrant Zip14 expression and increased zinc ion levels in cachectic muscles. Moreover, in advanced PDAC patients, high levels of ZIP14 in muscles correlated with the presence of cachexia. These studies underscore the importance of altered ZIP14 function in PDAC-associated cachexia development and highlight a potential therapeutic opportunity for improving the quality of life and prolonging survival in PDAC patients. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2072-6694 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1a8406b507aac0746b8931b0f9f4a18Test http://europepmc.org/articles/PMC7016633Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....f1a8406b507aac0746b8931b0f9f4a18 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20726694 |
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