Proteomic Profiling Differentiates Lymphoma Patients with and without Concurrent Myeloproliferative Neoplasia
| العنوان: | Proteomic Profiling Differentiates Lymphoma Patients with and without Concurrent Myeloproliferative Neoplasia |
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| المؤلفون: | Maja Ludvigsen, Michael Roost Clausen, Bent Honoré, Stephen Hamilton-Dutoit, Trine Engelbrecht Hybel, Marie Beck Enemark, Martin Bjerregaard Pedersen, Trine Lindhardt Plesner, Henrik Frederiksen, Michael Boe Møller, Kristina Lystlund Lauridsen, Peter Nørgaard, Francesco d'Amore, Johanne Marie Holst |
| المصدر: | Cancers Holst, J M, Enemark, M B, Pedersen, M B, Lauridsen, K L, Hybel, T E, Clausen, M R, Frederiksen, H, Møller, M B, Nørgaard, P, Plesner, T L, Hamilton-Dutoit, S J, D’amore, F, Honoré, B & Ludvigsen, M 2021, ' Proteomic profiling differentiates lymphoma patients with and without concurrent myeloproliferative neoplasia ', Cancers, vol. 13, no. 21, 5526 . https://doi.org/10.3390/cancers13215526Test Volume 13 Issue 21 Cancers, Vol 13, Iss 5526, p 5526 (2021) |
| بيانات النشر: | MDPI, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Proteomics, Cancer Research, Myeloid, Population, angioimmunoblastic T-cell lymphoma (AITL), IDH2, Article, Pathogenesis, proteomics, Downregulation and upregulation, immune system diseases, hemic and lymphatic diseases, medicine, Diffuse large B-cell lymphoma (DLBCL), Myeloproliferative neoplasia (MPN), education, RC254-282, myeloproliferative neoplasia (MPN), education.field_of_study, business.industry, Angioimmunoblastic T-cell lymphoma (AITL), Neoplasms. Tumors. Oncology. Including cancer and carcinogens, food and beverages, medicine.disease, Lymphoma, medicine.anatomical_structure, diffuse large B-cell lymphoma (DLBCL), Oncology, Cancer research, Immunohistochemistry, business |
| الوصف: | Simple Summary Patients are diagnosed with myeloproliferative neoplasia (MPN) and lymphoma more frequently in the population than expected, which has led to the hypothesis that the two malignancies may, in some cases, be pathogenetically related. In this study, lymphoma patients with and without MPN show subtle but important differences in the protein expression that enables the clustering of the lymphomas, thus indicating the differences at the molecular level between the lymphoma malignancies with and without MPN, and strengthening the hypothesis that the lymphoma and MPN may be biologically related. Abstract Myeloproliferative neoplasia (MPN) and lymphoma are regarded as distinct diseases with different pathogeneses. However, patients that are diagnosed with both malignancies occur more frequently in the population than expected. This has led to the hypothesis that the two malignancies may, in some cases, be pathogenetically related. Using a mass spectrometry-based proteomic approach, we show that pre-treatment lymphoma samples from patients with both MPN and lymphoma, either angioimmunoblastic T-cell lymphoma (MPN-AITL) or diffuse large B-cell lymphoma (MPN-DLBCL), show differences in protein expression compared with reference AITL or DLBCL samples from patients without MPN. A distinct clustering of samples from patients with and without MPN was evident for both AITL and DLBCL. Regarding MPN-AITL, a pathway analysis revealed disturbances of cellular respiration as well as oxidative metabolism, and an immunohistochemical evaluation further demonstrated the differential expression of citrate synthase and DNAJA2 protein (p = 0.007 and p = 0.015). Interestingly, IDH2 protein also showed differential expression in the MPN-AITL patients, which contributes to the growing evidence of this protein’s role in both myeloid neoplasia and AITL. In MPN-DLBCL, the disturbed pathways included a significant downregulation of protein synthesis as well as a perturbation of signal transduction. These results imply an underlying disturbance of tumor molecular biology, and in turn an alternative pathogenesis for tumors in these patients with both myeloid and lymphoid malignancies. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2072-6694 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d08ace5f59f08bfa5a6936c4c22bddaTest http://europepmc.org/articles/PMC8583469Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....3d08ace5f59f08bfa5a6936c4c22bdda |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20726694 |
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