Melanoma and the Unfolded Protein Response
| العنوان: | Melanoma and the Unfolded Protein Response |
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| المؤلفون: | Swetlana Mactier, Erin K. Sykes, Richard I. Christopherson |
| المصدر: | Cancers Cancers, Vol 8, Iss 3, p 30 (2016) |
| بيانات النشر: | MDPI, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | 0301 basic medicine, Cancer Research, endocrine system, Cell, Review, UPR, Biology, Bioinformatics, lcsh:RC254-282, environment and public health, digestive system, Metastasis, 03 medical and health sciences, 0302 clinical medicine, Downregulation and upregulation, medicine, melanoma, Endoplasmic reticulum, Melanoma, fungi, Cancer, unfolded protein response, medicine.disease, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, 030104 developmental biology, medicine.anatomical_structure, Oncology, Apoptosis, 030220 oncology & carcinogenesis, biological sciences, Unfolded protein response, Cancer research, ER stress |
| الوصف: | The UPR (unfolded protein response) has been identified as a key factor in the progression and metastasis of cancers, notably melanoma. Several mediators of the UPR are upregulated in cancers, e.g., high levels of GRP78 (glucose-regulator protein 78 kDa) correlate with progression and poor outcome in melanoma patients. The proliferative burden of cancer induces stress and activates several cellular stress responses. The UPR is a tightly orchestrated stress response that is activated upon the accumulation of unfolded proteins within the ER (endoplasmic reticulum). The UPR is designed to mediate two conflicting outcomtes, recovery and apoptosis. As a result, the UPR initiates a widespread signaling cascade to return the cell to homeostasis and failing to achieve cellular recovery, initiates UPR-induced apoptosis. There is evidence that ER stress and subsequently the UPR promote tumourigenesis and metastasis. The complete role of the UPR has yet to be defined. Understanding how the UPR allows for adaption to stress and thereby assists in cancer progression is important in defining an archetype of melanoma pathology. In addition, elucidation of the mechanisms of the UPR may lead to development of effective treatments of metastatic melanoma. |
| اللغة: | English |
| تدمد: | 2072-6694 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a904b4f6fbdf68dcb65bf42f7ee6524Test http://europepmc.org/articles/PMC4810114Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....9a904b4f6fbdf68dcb65bf42f7ee6524 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20726694 |
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