Telomerase Biogenesis and Activities from the Perspective of Its Direct Interacting Partners
| العنوان: | Telomerase Biogenesis and Activities from the Perspective of Its Direct Interacting Partners |
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| المؤلفون: | Kathryn T T T Nguyen, Judy M. Y. Wong |
| المصدر: | Cancers Cancers, Vol 12, Iss 1679, p 1679 (2020) |
| بيانات النشر: | MDPI, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, Cancer Research, Cell type, Telomerase, Chemistry, Protein subunit, TERT, Cell, Review, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, lcsh:RC254-282, Telomere, Cell biology, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, medicine.anatomical_structure, Oncology, Downregulation and upregulation, 030220 oncology & carcinogenesis, TERT interacting proteins, medicine, Telomerase reverse transcriptase, TERT non-telomeric functions, Biogenesis |
| الوصف: | Telomerase reverse transcriptase (TERT)—the catalytic subunit of telomerase—is reactivated in up to 90% of all human cancers. TERT is observed in heterogenous populations of protein complexes, which are dynamically regulated in a cell type- and cell cycle-specific manner. Over the past two decades, in vitro protein–protein interaction detection methods have discovered a number of endogenous TERT binding partners in human cells that are responsible for the biogenesis and functionalization of the telomerase holoenzyme, including the processes of TERT trafficking between subcellular compartments, assembly into telomerase, and catalytic action at telomeres. Additionally, TERT have been found to interact with protein species with no known telomeric functions, suggesting that these complexes may contribute to non-canonical activities of TERT. Here, we survey TERT direct binding partners and discuss their contributions to TERT biogenesis and functions. The goal is to review the comprehensive spectrum of TERT pro-malignant activities, both telomeric and non-telomeric, which may explain the prevalence of its upregulation in cancer. |
| اللغة: | English |
| تدمد: | 2072-6694 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe182cb59b08f190cba4e11751cb3784Test http://europepmc.org/articles/PMC7352425Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....fe182cb59b08f190cba4e11751cb3784 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20726694 |
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