التفاصيل البيبلوغرافية
العنوان:
Changing trends in prognostic factors for patients with multiple myeloma after autologous stem cell transplantation during the immunomodulator drug/proteasome inhibitor era
المؤلفون:
Kazutaka Sunami , Hisashi Sakamaki , Shinsuke Iida , Sumihisa Honda , Hiroyuki Takamatsu , Toshihiro Iwasaki , Shotaro Hagiwara , Toshihiro Miyamoto , Ritsuro Suzuki , Naoto Tomita , Kenji Yokoyama , Toshiro Ito
المصدر:
Cancer Science
بيانات النشر:
日本癌学会 = The Japanese Cancer Association / Blackwell Publishing Ltd, 2015.
سنة النشر:
2015
مصطلحات موضوعية:
Oncology , Adult , Male , Cancer Research , medicine.medical_specialty , Adolescent , International Staging System , medicine.medical_treatment , proteasome inhibitors , Hematopoietic stem cell transplantation , Autologous stem cell transplantation , Transplantation, Autologous , immunomodulator drugs , Young Adult , Autologous stem-cell transplantation , Adjuvants, Immunologic , Internal medicine , Antineoplastic Combined Chemotherapy Protocols , medicine , Humans , Immunologic Factors , Clinical significance , Survival rate , Multiple myeloma , Aged , Retrospective Studies , Very Good Partial Response , Performance status , business.industry , Hematopoietic Stem Cell Transplantation , General Medicine , Original Articles , Middle Aged , medicine.disease , Prognosis , Surgery , Survival Rate , multiple myeloma , Proteasome inhibitor , Female , business , medicine.drug
الوصف:
We evaluated the clinical significance of prognostic factors including the International Staging System (ISS) and modified European Group for Blood and Marrow Transplantation response criteria in 1650 Japanese patients with multiple myeloma (MM) who underwent upfront single autologous stem cell transplantation (ASCT). We categorized patients into two treatment cohorts: pre-novel agent era (1995-2006) and novel agent era (2008-2011). The combined percentage of pre-ASCT complete response and very good partial response cases (463 of 988, 47%) significantly increased during the novel agent era compared with the pre-novel agent era (164 of 527, 31%; P < 0.0001). The 2-year overall survival (OS) rate of 87% during the novel agent era was a significant improvement relative to that of 82% during the pre-novel agent era (P = 0.019). Although significant differences in OS were found among ISS stages during the pre-novel agent era, no significant difference was observed between ISS I and II (P = 0.107) during the novel agent era. The factors independently associated with a superior OS were female gender (P = 0.002), a good performance status (P = 0.024), lower ISS (P < 0.001), pre-ASCT response at least partial response (P < 0.001) and ASCT during the novel agent era (P = 0.017). These results indicate that the response rate and OS were significantly improved, and the ISS could not clearly stratify the prognoses of Japanese patients with MM who underwent upfront single ASCT during the novel agent era. © 2014 The Authors. Cancer Science published by Wiley Publishing Asia Pty Ltd on behalf of Japanese Cancer Association.
اللغة:
English
تدمد:
1349-7006
الوصول الحر:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8fbaaa180fcdea600b9aa119a98210fTest http://hdl.handle.net/2297/43450Test
حقوق:
OPEN
رقم الانضمام:
edsair.doi.dedup.....a8fbaaa180fcdea600b9aa119a98210f
قاعدة البيانات:
OpenAIRE
