التفاصيل البيبلوغرافية
| العنوان: |
Systemic Inflammatory Biomarkers, Especially Fibrinogen to Albumin Ratio, Predict Prognosis in Patients with Pancreatic Cancer. |
| المؤلفون: |
Lin Fang1,2, Fei-Hu Yan1, Chao Liu1,2, Jing Chen3, Dan Wang1, Chun-Hui Zhang1, Chang-Jie Lou1, Jie Lian1,2, Yang Yao1,2, Bo-Jun Wang1,2, Rui-Yang Li1, Shu-Ling Han1, Yi-Bing Bai1, Jia-Ni Yang1, Zhi-Wei Li1 lzhw0451@163.com, Yan-Qiao Zhang1,2 yanqiaozhang@ems.hrbmu.edu.cn |
| المصدر: |
Cancer Research & Treatment. Jan2021, Vol. 53 Issue 1, p131-139. 9p. |
| مصطلحات موضوعية: |
*PANCREATIC cancer, *PROGNOSIS, *PROPORTIONAL hazards models, *FIBRINOGEN, *NEUTROPHIL lymphocyte ratio |
| مستخلص: |
Purpose Systemic inflammatory response is a critical factor that promotes the initiation and metastasis of malignancies including pancreatic cancer (PC). This study was designed to determine and compare the prognostic value of neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), and fibrinogen-to-albumin ratio (FAR) in resectable PC and locally advanced or metastatic PC. Materials and Methods Three hundred fifty-three patients with resectable PC and 807 patients with locally advan-ced or metastatic PC were recruited in this study. These patients were classified into a training set (n=758) and a validation set (n=402). Kaplan-Meier survival plots and Cox proportional hazards regression models were used to analyze prognosis. Results Overall survival (OS) was significantly better for patients with resectable PC with low preoperative PLR (p=0.048) and MLR (p=0.027). Low FAR, MLR, NLR (p < 0.001), and PLR (p=0.003) were significantly associated with decreased risk of death for locally advanced or metastatic PC patients. FAR (hazard ratio [HR], 1.522; 95% confidential interval [CI], 1.261 to 1.837; p < 0.001) and MLR (HR, 1.248; 95% CI, 1.017 to 1.532; p=0.034) were independent prognostic factors for locally advanced or metastatic PC. Conclusion The prognostic roles of FAR, MLR, NLR, and PLR in resectable PC and locally advanced or metastatic PC were different. FAR showed the most prognostic power in locally advanced or metastatic PC. Low FAR was positively correlated with OS in locally advanced or metastatic PC, which could be used to predict the prognosis. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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