التفاصيل البيبلوغرافية
| العنوان: |
STAT3 Plays a Critical Role in KRAS-Induced Pancreatic Tumorigenesis. |
| المؤلفون: |
Corcoran, Ryan B.1,2, Contino, Gianmarco1,2,3, Deshpande, Vikram4,5, Tzatsos, Alexandros1,2, Conrad, Claudius1, Benes, Cyril H.1,2, Levy, David E.6, Settleman, Jeffrey1,2, Engelman, Jeffrey A.1,2, Bardeesy, Nabeel1,2 Bardeesy.Nabeel@mgh.harvard.edu |
| المصدر: |
Cancer Research. Jul2011, Vol. 71 Issue 14, p5020-5029. 10p. |
| مصطلحات موضوعية: |
*TRANSCRIPTION factors, *PANCREATIC duct, *ADENOCARCINOMA, *CARCINOGENESIS, *TYROSINE, *PHOSPHORYLATION, *CANCER |
| مستخلص: |
The article presents a study which defined the mechanisms of STAT3 transcription factor activation and its functional importance in pancreatic ductal adenocarcinoma (PDAC) pathogenesis. The analysis revealed a close correlation of sensitivity with levels of tyrosine-phosphorylated STAT3 and of the gp 130 receptor, an upstream signaling component. It has found that STAT3 supports the development of therapeutic approaches targeting this pathway. |
| قاعدة البيانات: |
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