Outcomes and risk of subsequent breast events in breast-conserving surgery patients with BRCA1 and BRCA2 mutation
| العنوان: | Outcomes and risk of subsequent breast events in breast-conserving surgery patients with BRCA1 and BRCA2 mutation |
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| المؤلفون: | Genhong Di, Liang Huang, Xin Hu, Fugui Ye, Guan-Tian Lang, Zhimin Shao, A-Yong Cao |
| المصدر: | Cancer Medicine Cancer Medicine, Vol 9, Iss 5, Pp 1903-1910 (2020) |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | 0301 basic medicine, Oncology, Cancer Research, medicine.medical_treatment, Mastectomy, Segmental, outcomes, 0302 clinical medicine, BRCA2 Mutation, Risk Factors, Breast-conserving surgery, Breast, skin and connective tissue diseases, Original Research, breast‐conserving surgery, BRCA1 Protein, Confounding, Carcinoma, Ductal, Breast, Middle Aged, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Prognosis, subsequent breast events, 030220 oncology & carcinogenesis, Practice Guidelines as Topic, Female, Cancer Prevention, Adult, medicine.medical_specialty, China, Heterozygote, Clinical Decision-Making, Breast Neoplasms, lcsh:RC254-282, Risk Assessment, Disease-Free Survival, 03 medical and health sciences, Breast cancer, breast cancer, Internal medicine, medicine, Humans, Radiology, Nuclear Medicine and imaging, Genetic Predisposition to Disease, Risk factor, Pathological, Germ-Line Mutation, Retrospective Studies, BRCA2 Protein, business.industry, BRCA mutation, BRCA1/2 mutation, medicine.disease, Cancer registry, 030104 developmental biology, Prophylactic Mastectomy, Neoplasm Recurrence, Local, business |
| الوصف: | Purpose Previous studies provide inconsistent interpretations of the effect of inherited genetic factors on the survival and prognosis of patients with breast cancer. The aim of this study was to examine the effect of germline BRCA1 and BRCA2 mutation on survival and subsequent breast events in Chinese women who underwent breast‐conserving surgery. Methods A retrospective review of the clinical and pathological records was performed in patients diagnosed with primary invasive breast cancer between 2005 and 2018 in the cancer registry database. Clinicopathological data and data regarding treatment and outcomes, including date and site of disease progression, were collected. The survival outcomes and independent risk factors were conducted using SPSS. Results Overall, a total of 501 patients who underwent breast‐conserving surgery were identified and subjected to analyses, of which 63 cases with BRCA1 or BRCA2 mutation. The median age at diagnosis was 41 (range, 24‐74) for carriers and 37 (range, 17‐84) for noncarriers. After a median follow‐up time of 61 months (range, 8‐161) and 70 months (range, 0‐153), respectively, in carriers and noncarriers, the overall survival (P = .173) and disease‐free survival (P = .424) were not significantly different. Analogously, there was no significant difference between the two groups about the outcomes of ipsilateral breast tumor recurrence (P = .348), yet the contralateral breast cancer (CBC) was overt worse than noncarriers (P In our retrospective study, we conclude that breast‐conserving surgery is a reasonably safe and effective option for patients carrying a BRCA1 or BRCA2 mutation in China. BRCA mutation carriers have higher risk of CBC, and is the only independent risk factor to CBC. Decisions on alternatively effective prevention are urgent and should take into account patient prognosis and preferences. |
| تدمد: | 2045-7634 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::017caf6883248a3fc8158f8bd6ee98c0Test https://pubmed.ncbi.nlm.nih.gov/31912664Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....017caf6883248a3fc8158f8bd6ee98c0 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20457634 |
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