The Effects of smoking status and smoking history on patients with brain metastases from lung cancer

التفاصيل البيبلوغرافية
العنوان: The Effects of smoking status and smoking history on patients with brain metastases from lung cancer
المؤلفون: Marcelo Bonomi, Natalie K. Alphonse-Sullivan, R.F. Shenker, Michael D. Chan, Kounosuke Watabe, William J. Petty, Michael Farris, Kathryn E. Weaver, Emory R. McTyre, Adrian W. Laxton, Jimmy Ruiz, Christina K. Cramer, Graham W. Warren, Stephen B. Tatter
المصدر: Cancer Medicine
بيانات النشر: John Wiley and Sons Inc., 2017.
سنة النشر: 2017
مصطلحات موضوعية: 0301 basic medicine, Oncology, Male, Cancer Research, Multivariate analysis, Lung Neoplasms, medicine.medical_treatment, 0302 clinical medicine, Original Research, Aged, 80 and over, Brain Neoplasms, Smoking, Middle Aged, 3. Good health, medicine.anatomical_structure, Treatment Outcome, 030220 oncology & carcinogenesis, Adenocarcinoma, Female, Adult, medicine.medical_specialty, stereotactic radiosurgery, Radiosurgery, Disease-Free Survival, 03 medical and health sciences, Internal medicine, medicine, Humans, Radiology, Nuclear Medicine and imaging, brain metastasis velocity, Lung cancer, Survival analysis, Aged, Retrospective Studies, Lung, business.industry, Clinical Cancer Research, Retrospective cohort study, Brain metastases, medicine.disease, Survival Analysis, Surgery, smoking cessation, lung cancer, 030104 developmental biology, Smoking cessation, business, Brain metastasis
الوصف: There is limited data on the effects of smoking on lung cancer patients with brain metastases. This single institution retrospective study of patients with brain metastases from lung cancer who received stereotactic radiosurgery assessed whether smoking history is associated with overall survival, local control, rate of new brain metastases (brain metastasis velocity), and likelihood of neurologic death after brain metastases. Patients were stratified by adenocarcinoma versus nonadenocarcinoma histologies. Kaplan–Meier analysis was performed for survival endpoints. Competing risk analysis was performed for neurologic death analysis to account for risk of nonneurologic death. Separate linear regression and multivariate analyses were performed to estimate the brain metastasis velocity. Of 366 patients included in the analysis, the median age was 63, 54% were male and, 60% were diagnosed with adenocarcinoma. Current smoking was reported by 37% and 91% had a smoking history. Current smoking status and pack‐year history of smoking had no effect on overall survival. There was a trend for an increased risk of neurologic death in nonadenocarcinoma patients who continued to smoke (14%, 35%, and 46% at 6/12/24 months) compared with patients who did not smoke (12%, 23%, and 30%, P = 0.053). Cumulative pack years smoking was associated with an increase in neurologic death for nonadenocarcinoma patients (HR = 1.01, CI: 1.00–1.02, P = 0.046). Increased pack‐year history increased brain metastasis velocity in multivariate analysis for overall patients (P = 0.026). Current smokers with nonadenocarcinoma lung cancers had a trend toward greater neurologic death than nonsmokers. Cumulative pack years smoking is associated with a greater brain metastasis velocity.
اللغة: English
تدمد: 2045-7634
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9267dc7d37df3dc4424e83fd7d4cca25Test
http://europepmc.org/articles/PMC5430088Test
حقوق: OPEN
رقم الانضمام: edsair.doi.dedup.....9267dc7d37df3dc4424e83fd7d4cca25
قاعدة البيانات: OpenAIRE