التفاصيل البيبلوغرافية
| العنوان: |
Prognostic impact of p53 protein overexpression in patients with node-negative lung adenocarcinoma |
| المؤلفون: |
Suzuki, Hiroyuki1 hiro@fmu.ac.jp, Kawaguchi, Takanori2, Hasegawa, Takeo1, Yonechi, Atsushi1, Ohsugi, Jun1, Higuchi, Mitsunori1, Yamada, Fumihiko1, Shio, Yutaka1, Fujiu, Koichi1, Kanno, Ryuzo1, Ohishi, Akio3, Gotoh, Mitsukazu1 |
| المصدر: |
Cancer Letters. Jun2006, Vol. 237 Issue 2, p242-247. 6p. |
| مصطلحات موضوعية: |
*P53 protein, *ADENOCARCINOMA, *PROGNOSIS, *CANCER |
| مستخلص: |
Abstract: Prognostic value of p53 protein expression in node-negative lung adenocarcinoma is still controversy. The expression of p53 protein was examined immunohistochemically in lung adenocarcinoma using monoclonal antibody BP53-12. A total 131 cases of primary lung adenocarcinoma were examined. Relationship between expression of p53 protein and clinicopathologic factors were studied. Overexpression of p53 protein was found in 19 patients (14.5%). Univariate and multivariate analysis showed that overexpression of p53 protein was an independent prognostic factor in node-negative lung adenocarcinoma. p53 alteration could be a valuable predictor for prognosis in node-negative lung adenocarcinoma. [Copyright &y& Elsevier] |
| قاعدة البيانات: |
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