Long-term Complete Remission Following Radiosurgery and Immunotherapy in a Melanoma Patient with Brain Metastasis: Immunologic Correlates
| العنوان: | Long-term Complete Remission Following Radiosurgery and Immunotherapy in a Melanoma Patient with Brain Metastasis: Immunologic Correlates |
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| المؤلفون: | Elke Jäger, Alexander Knuth, Helga Bernhard, Claudia Wahle, Kathrin Brandt, Sacha Gnjatic, Eckhart Weidmann, Akin Atmaca, Melina Biskamp, Julia Karbach |
| المصدر: | Cancer Immunology Research. 2:404-409 |
| بيانات النشر: | American Association for Cancer Research (AACR), 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Adult, Oncology, Cancer Research, medicine.medical_specialty, medicine.medical_treatment, Immunology, T-Cell Antigen Receptor Specificity, CD8-Positive T-Lymphocytes, Radiosurgery, Cancer Vaccines, Antibodies, Antigens, Neoplasm, Internal medicine, medicine, Humans, Melanoma, Melanoma patient, biology, Brain Neoplasms, business.industry, Remission Induction, Complete remission, Membrane Proteins, Dendritic Cells, Immunotherapy, medicine.disease, Vaccination, Treatment Outcome, biology.protein, Female, Antibody, business, CD8, Follow-Up Studies, Brain metastasis |
| الوصف: | A melanoma patient with brain metastases was treated by gamma-knife radiosurgery and immunotherapy with autologous tumor-lysate–loaded dendritic cells (DC). Ten years after the combined treatment, the patient remains in complete remission. Remarkable immunologic correlates to the clinical development were the transient induction of NY-ESO-1 antibody and the durable expansion of MAGE-A1p161–169 EADPTGHSY–specific CD8+ T cells. Although the induction of NY-ESO-1 antibody most likely resulted from gamma-knife–mediated “auto-vaccination,” the persistence of circulating MAGE-A1–specific T cells, which are still detectable ex vivo in the absence of any tumor manifestation, coincides with DC-based vaccination administered monthly until today. Cancer Immunol Res; 2(5); 404–9. ©2014 AACR. |
| تدمد: | 2326-6074 2326-6066 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1a0ded218d4014cfcaeb19d6773c304Test https://doi.org/10.1158/2326-6066.cir-13-0200Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....d1a0ded218d4014cfcaeb19d6773c304 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 23266074 23266066 |
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