Assessment of tissue perfusion of pancreatic cancer as potential imaging biomarker by means of Intravoxel incoherent motion MRI and CT perfusion: correlation with histological microvessel density as ground truth
| العنوان: | Assessment of tissue perfusion of pancreatic cancer as potential imaging biomarker by means of Intravoxel incoherent motion MRI and CT perfusion: correlation with histological microvessel density as ground truth |
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| المؤلفون: | Hans-Ulrich Kauczor, Matthias M. Gaida, Frank Bergmann, Thilo Hackert, Miriam Klauß, Philipp Mayer, Klaus H. Maier-Hein, Lars Grenacher, Wolfram Stiller, Marco Koell, Franziska Fritz, Stephan Skornitzke, Frederik Bernd Laun |
| المصدر: | Cancer Imaging, Vol 21, Iss 1, Pp 1-12 (2021) Cancer Imaging |
| بيانات النشر: | BMC, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Male, lcsh:Medical physics. Medical radiology. Nuclear medicine, Imaging biomarker, Diffusion magnetic resonance imaging, lcsh:R895-920, Perfusion scanning, Adenocarcinoma, lcsh:RC254-282, 030218 nuclear medicine & medical imaging, Pancreatic ductal adenocarcinoma, 03 medical and health sciences, Motion, 0302 clinical medicine, Parenchyma, Medicine, Humans, Radiology, Nuclear Medicine and imaging, ddc:610, Prospective Studies, Microvessel, Intravoxel incoherent motion, X-ray computed tomography, Radiological and Ultrasound Technology, Receiver operating characteristic, business.industry, General Medicine, Blood flow, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Magnetic Resonance Imaging, Perfusion, Oncology, 030220 oncology & carcinogenesis, Microvessels, Female, Nuclear medicine, business, Tomography, X-Ray Computed, Microvascular Density, Carcinoma, Pancreatic Ductal, Research Article |
| الوصف: | Background/objectives The aim of this study was to compare intravoxel incoherent motion (IVIM) diffusion weighted (DW) MRI and CT perfusion to assess tumor perfusion of pancreatic ductal adenocarcinoma (PDAC). Methods In this prospective study, DW-MRI and CT perfusion were conducted in nineteen patients with PDAC on the day before surgery. IVIM analysis of DW-MRI was performed and the parameters perfusion fraction f, pseudodiffusion coefficient D*, and diffusion coefficient D were extracted for tumors, upstream, and downstream parenchyma. With a deconvolution-based analysis, the CT perfusion parameters blood flow (BF) and blood volume (BV) were estimated for tumors, upstream, and downstream parenchyma. In ten patients, intratumoral microvessel density (MVDtumor) and microvessel area (MVAtumor) were analyzed microscopically in resection specimens. Correlation coefficients between IVIM parameters, CT perfusion parameters, and histological microvessel parameters in tumors were calculated. Receiver operating characteristic (ROC) analysis was performed for differentiation of tumors and upstream parenchyma. Results ftumor significantly positively correlated with BFtumor (r = 0.668, p = 0.002) and BVtumor (r = 0.672, p = 0.002). There were significant positive correlations between ftumor and MVDtumor/ MVAtumor (r ≥ 0.770, p ≤ 0.009) as well as between BFtumor and MVDtumor/ MVAtumor (r ≥ 0.697, p ≤ 0.025). Correlation coefficients between ftumor and MVDtumor/ MVAtumor were not significantly different from correlation coefficients between BFtumor and MVDtumor/ MVAtumor (p ≥ 0.400). Moreover, f, BF, BV, and permeability values (PEM) showed excellent performance in distinguishing tumors from upstream parenchyma (area under the ROC curve ≥0.874). Conclusions The study shows that IVIM derived ftumor and CT perfusion derived BFtumor similarly reflect vascularity of PDAC and seem to be comparably applicable for the evaluation of tumor perfusion for tumor characterization and as potential quantitative imaging biomarker. Trial registration DRKS, DRKS00022227, Registered 26 June 2020, retrospectively registered. https://www.drks.de/drks_web/navigate.do?navigationId=trialTest. HTML&TRIAL_ID=DRKS00022227. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1470-7330 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d98b712287994327407a050cde0aa7d5Test https://doaj.org/article/c8267730479f42b69bb8de686bec0a62Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....d98b712287994327407a050cde0aa7d5 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14707330 |
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