Comparative clinical and transcriptomal profiles of breast cancer between French and South Mediterranean patients show minor but significative biological differences
| العنوان: | Comparative clinical and transcriptomal profiles of breast cancer between French and South Mediterranean patients show minor but significative biological differences |
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| المؤلفون: | Chalabi, Nasséra, Bernard-Gallon, Dominique J, Bignon, Yves Jean, Kwiatkowski, Fabrice G, Agier, M, Vidal, V., Laplace-Chabaud, V, Sylvain-Vidal, Valérie, Bertholet, Vincent, De Longueville, Françoise, Lacroix, Marc, Leclercq, Guy, Remacle, Josè A, Sibille, Catherine, Zammateo, N, Ben Jaafar, N, Sefiani, Abdelaziz, Ouldim, Karim, Mégarbané, André, Jalkh, Nadine, Mahfoudh, Wijden, Troudi, Wafa, Ben Ammar-El Gaïed, A., Chouchane, Lotfi |
| المساهمون: | Centre Jean Perrin [Clermont-Ferrand] (UNICANCER/CJP), UNICANCER, Centre de Recherche en Nutrition Humaine Auvergne [CHU Clermont-Ferrand] (CRNH A), Direction de la recherche clinique et de l’innovation [CHU Clermont-Ferrand] (DRCI), CHU Clermont-Ferrand-CHU Clermont-Ferrand, Université d'Auvergne - Clermont-Ferrand I (UdA), Eppendorf Array Technologies S.A. [Namur], Institut National d'Hygiène [Maroc], Université Saint-Joseph de Beyrouth (USJ), Laboratoire d'immunologie clinique [Institut Pasteur de Tunis], Institut Pasteur de Tunis, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Faculté de Médecine de Monastir [Tunisie], The 'Breast Med Consortium' is a European project linked by a contract n° ICA3-CT-2002-10005. This work was supported by grants from 'La Ligue Nationale Française de Lutte Contre le Cancer' and 'Les Comité du Puy-de-Dôme et du Cantal'., We thank T. Jalabert and J. Fayolle from the 'Departement d'Oncogénétique' of Centre Jean Perrin for technical assistance. |
| المصدر: | Cancer Genomics and Proteomics Cancer Genomics and Proteomics, International Institute of Anticancer Research, 2008, 5 (5), pp.253-61 |
| سنة النشر: | 2009 |
| مصطلحات موضوعية: | MESH: Carcinoma, Lobular/genetics, Tunisia, MESH: Gene Expression Profiling, [SDV]Life Sciences [q-bio], MESH: Biomarkers, Tumor/genetics, MESH: Gene Expression Regulation, Neoplastic, Breast Neoplasms, MESH: Carcinoma, Ductal, Breast/secondary, MESH: Carcinoma, Ductal, Breast/metabolism, MESH: Prognosis, Breast cancer, Prohibitins, MESH: Oligonucleotide Array Sequence Analysis/methods, Biomarkers, Tumor, Humans, MESH: Carcinoma, Lobular/secondary, MESH: Lebanon, Lebanon, microarrays, MESH: Breast Neoplasms/pathology, clinical parameters, MESH: Carcinoma, Lobular/metabolism, Oligonucleotide Array Sequence Analysis, MESH: Humans, MESH: Middle Aged, Gene Expression Profiling, Carcinoma, Ductal, Breast, MESH: Carcinoma, Ductal, Breast/genetics, Middle Aged, Prognosis, MESH: Breast Neoplasms/genetics, MESH: France, Gene Expression Regulation, Neoplastic, Carcinoma, Lobular, Morocco, MESH: Breast Neoplasms/metabolism, MESH: Morocco, Female, European and Mediterranean countries, France, MESH: Tunisia, MESH: Female |
| الوصف: | Erratum in :Cancer Genomics Proteomics. 2008 Nov-Dec;5(6):353.Cancer Genomics Proteomics. 2009 Jan-Feb;6(1):73.; International audience; BACKGROUND: In Western countries, breast cancer incidence and mortality are higher than in Mediterranean countries. These differences have been ascribed to environmental factors but also to late-stage diagnostic and biological specific characteristics.PATIENTS AND METHODS: Between September 2002 and September 2005, we collected clinical data by phone counselling 180 French and Mediterranean breast cancer patients and performed microarray experiments.RESULTS: Characteristics of breast cancer in patients from Lebanon, Tunisia and Morocco were more aggressive (more SBR grade III and positive node invasion) and patients were 10 years younger at diagnosis. Sixteen differentially expressed genes such as MMP9, VEGF, PHB1, BRCA1, TFAP2C, GJA1 and TFF1 were also found. Additionally, an up-regulation of cytokeratins KRT8 and KRT18 may indicate a luminal B subtype in "South" (Lebanon, Tunisia and Morocco) tumors while "North" (France) tumors may more frequently be luminal A type.CONCLUSION: This study allowed the identification of specific clinical and transcriptomic parameters in patients from South Mediterranean countries. |
| تدمد: | 1109-6535 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::ed993ffd69d20eaf227db9ae892a2f26Test https://pubmed.ncbi.nlm.nih.gov/19129556Test |
| رقم الانضمام: | edsair.pmid.dedup....ed993ffd69d20eaf227db9ae892a2f26 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 11096535 |
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