Case Fatality Rate of Cancer Patients with COVID-19 in a New York Hospital System
| العنوان: | Case Fatality Rate of Cancer Patients with COVID-19 in a New York Hospital System |
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| المؤلفون: | Raja Thota, Benjamin A. Gartrell, Nitin Ohri, Andrew D. Racine, Balazs Halmos, Roman Perez-Soler, Mendel Goldfinger, Richard V. Smith, Joseph A. Sparano, Daniel Cole, Rafi Kabarriti, Ana Acuna-Villaorduna, Amit Verma, Sanjay Goel, Madhur Garg, Shalom Kalnicki, Stan H. Reissman, Vikas Mehta, Kith Pradhan |
| المصدر: | Radiotherapy and Oncology Cancer Discovery |
| بيانات النشر: | American Association for Cancer Research (AACR), 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Adult, Male, 0301 basic medicine, medicine.medical_specialty, Multivariate analysis, Adolescent, medicine.medical_treatment, Pneumonia, Viral, New York, Disease, Research Brief, Malignancy, Betacoronavirus, Young Adult, 03 medical and health sciences, Hospitals, Urban, 0302 clinical medicine, Neoplasms, Internal medicine, Case fatality rate, medicine, Humans, Young adult, Child, Lung cancer, Pandemics, Letter to the Editor, Aged, Aged, 80 and over, SARS-CoV-2, business.industry, COVID-19, Infant, Cancer, Immunosuppression, Middle Aged, medicine.disease, 030104 developmental biology, Oncology, Spain, Child, Preschool, 030220 oncology & carcinogenesis, Radiation Oncology, Female, Coronavirus Infections, business |
| الوصف: | Patients with cancer in a New York hospital system were much more vulnerable to COVID-19 death than the general population, with a case fatality rate that varied by cancer type and was 28% overall. Patients with cancer are presumed to be at increased risk from COVID-19 infection–related fatality due to underlying malignancy, treatment-related immunosuppression, or increased comorbidities. A total of 218 COVID-19–positive patients from March 18, 2020, to April 8, 2020, with a malignant diagnosis were identified. A total of 61 (28%) patients with cancer died from COVID-19 with a case fatality rate (CFR) of 37% (20/54) for hematologic malignancies and 25% (41/164) for solid malignancies. Six of 11 (55%) patients with lung cancer died from COVID-19 disease. Increased mortality was significantly associated with older age, multiple comorbidities, need for ICU support, and elevated levels of D-dimer, lactate dehydrogenase, and lactate in multivariate analysis. Age-adjusted CFRs in patients with cancer compared with noncancer patients at our institution and New York City reported a significant increase in case fatality for patients with cancer. These data suggest the need for proactive strategies to reduce likelihood of infection and improve early identification in this vulnerable patient population. Significance: COVID-19 in patients with cancer is associated with a significantly increased risk of case fatality, suggesting the need for proactive strategies to reduce likelihood of infection and improve early identification in this vulnerable patient population. This article is highlighted in the In This Issue feature, p. 890 |
| تدمد: | 2159-8290 2159-8274 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f81f1cd621dcd215f4d8024caaa3496Test https://doi.org/10.1158/2159-8290.cd-20-0516Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....6f81f1cd621dcd215f4d8024caaa3496 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 21598290 21598274 |
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