نتائج البحث

1

Metformin plus first-line chemotherapy versus chemotherapy alone in the treatment of epithelial ovarian cancer: a prospective open-label pilot trial

المؤلفون: Hong Sun, Jie Zhu, Ya Zheng, Haiyan Zhang, Yanmei Liu

المصدر: Cancer chemotherapy and pharmacology. 84(6)

مصطلحات موضوعية: 0301 basic medicine, Oncology, Cancer Research, endocrine system diseases, medicine.medical_treatment, Pilot Projects, Overweight, Carcinoma, Ovarian Epithelial, Toxicology, Carboplatin, chemistry.chemical_compound, 0302 clinical medicine, Antineoplastic Combined Chemotherapy Protocols, Clinical endpoint, Pharmacology (medical), Prospective Studies, Insulin-Like Growth Factor I, Ovarian Neoplasms, digestive, oral, and skin physiology, Cytoreduction Surgical Procedures, Middle Aged, Metformin, Progression-Free Survival, Paclitaxel, 030220 oncology & carcinogenesis, Female, medicine.symptom, medicine.drug, Signal Transduction, Adult, medicine.medical_specialty, Disease-Free Survival, Drug Administration Schedule, 03 medical and health sciences, Internal medicine, Diabetes mellitus, medicine, Humans, Hypoglycemic Agents, Pharmacology, Chemotherapy, business.industry, nutritional and metabolic diseases, medicine.disease, Clinical trial, Insulin-Like Growth Factor Binding Protein 1, 030104 developmental biology, chemistry, business

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d62c73f83dc7aa22b548603a660cc5d9Test
https://pubmed.ncbi.nlm.nih.gov/31628524Test

2

TAK-228 (formerly MLN0128), an investigational dual TORC1/2 inhibitor plus paclitaxel, with/without trastuzumab, in patients with advanced solid malignancies

المؤلفون: J. R. Infante, Carla Kurkjian, F. Zohren, Patrick Murphy, Howard A. Burris, Chirag Patel, Shubham Pant, Rachel Neuwirth, Lowell L. Hart, Suzanne F. Jones

المصدر: Cancer Chemotherapy and Pharmacology. 80:261-273

مصطلحات موضوعية: Male, 0301 basic medicine, Oncology, Cancer Research, Pharmacology, Toxicology, chemistry.chemical_compound, 0302 clinical medicine, Trastuzumab, Neoplasms, Antineoplastic Combined Chemotherapy Protocols, Pharmacology (medical), Aged, 80 and over, Benzoxazoles, Leukopenia, TOR Serine-Threonine Kinases, Combination chemotherapy, Middle Aged, Rash, Treatment Outcome, Paclitaxel, 030220 oncology & carcinogenesis, Female, medicine.symptom, medicine.drug, Adult, medicine.medical_specialty, Maximum Tolerated Dose, Nausea, Mechanistic Target of Rapamycin Complex 2, Mechanistic Target of Rapamycin Complex 1, Neutropenia, Young Adult, 03 medical and health sciences, Pharmacokinetics, Internal medicine, medicine, Humans, Aged, Dose-Response Relationship, Drug, business.industry, medicine.disease, Pyrimidines, 030104 developmental biology, chemistry, Multiprotein Complexes, business

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f25dd2c5c60a1063e2201f4e4bfb406Test
https://doi.org/10.1007/s00280-017-3343-4Test

3

Pazopanib interacts with irinotecan by inhibiting UGT1A1-mediated glucuronidation, but not OATP1B1-mediated hepatic uptake, of an active metabolite SN-38

المؤلفون: Yuji Kiuchi, Mariko Iwase, Natsumi Seba, Yuki Nishimura, Hiroo Ishida, Yusuke Masuo, Ken-ichi Fujita, Yukio Kato

المصدر: Cancer chemotherapy and pharmacology. 83(5)

مصطلحات موضوعية: 0301 basic medicine, Adult, Male, Cancer Research, Indazoles, Adolescent, medicine.drug_class, Glucuronidation, SN-38, Pharmacology, Toxicology, Irinotecan, Tyrosine-kinase inhibitor, Pazopanib, 03 medical and health sciences, chemistry.chemical_compound, Young Adult, 0302 clinical medicine, Pharmacokinetics, medicine, Humans, Pharmacology (medical), Drug Interactions, Glucuronosyltransferase, Protein Kinase Inhibitors, Active metabolite, Aged, Aged, 80 and over, Sulfonamides, Dose-Response Relationship, Drug, Chemistry, Liver-Specific Organic Anion Transporter 1, Middle Aged, 030104 developmental biology, HEK293 Cells, Pyrimidines, Oncology, Liver, 030220 oncology & carcinogenesis, Area Under Curve, Microsome, Microsomes, Liver, Female, Topoisomerase I Inhibitors, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aff82ff32606cbf22067484e8eb9261dTest
https://pubmed.ncbi.nlm.nih.gov/30810774Test

4

Prognostic significance of RACGAP1 mRNA expression in high-risk early breast cancer: a study in primary tumors of breast cancer patients participating in a randomized Hellenic Cooperative Oncology Group trial

المؤلفون: Pliarchopoulou, K., Kalogeras, K. T., Kronenwett, R., Wirtz, R. M., Eleftheraki, A. G., Batistatou, Anna, Bobos, M., Soupos, N., Polychronidou, G., Gogas, H., Samantas, E., Christodoulou, C., Makatsoris, T., Pavlidis, Nicholas, Pectasides, Dimitrios, Fountzilas, George

المساهمون: Pavlidis, Nicholas [0000-0002-2195-9961]

المصدر: Cancer chemotherapy and pharmacology

مصطلحات موضوعية: Oncology, Survival rate, Scoring system, Messenger rna, Cell, Toxicology, Breast cancer, Antineoplastic Combined Chemotherapy Protocols, Pharmacology (medical), Rac gtpase activating protein 1 gene, Ki-67 antigen, Quantitative analysis, Disease free survival, Survival time, Gene expression regulation, GTPase-Activating Proteins, Prognosis, Gene Expression Regulation, Neoplastic, Survival Rate, Retrospective study, Paclitaxel, Reverse transcription polymerase chain reaction, Regression Analysis, Human, medicine.medical_specialty, Major clinical study, Nottingham prognostic index, Disease-Free Survival, Article, Cancer grading, Randomized controlled trials as topic, Disease association, Humans, RNA, Messenger, Cyclophosphamide, Retrospective Studies, Aged, Pharmacology, Cancer prognosis, Patient Selection, medicine.disease, Retrospective studies, Drug effect, Ki-67 Antigen, Methotrexate, Gene identification, chemistry, Protein expression, Risk factor, Gene expression, Breast neoplasms, Cancer Research, Unclassified drug, Messenger, Metastasis, Qrt-pcr, Cancer risk, chemistry.chemical_compound, Randomized controlled trial (topic), Patient selection, Guanosine triphosphatase activating protein, Overall survival, Gtpase-activating proteins, Middle aged, Reverse transcriptase polymerase chain reaction, Randomized Controlled Trials as Topic, Priority journal, Risk assessment, Reverse Transcriptase Polymerase Chain Reaction, Middle Aged, Primary tumor, medicine.anatomical_structure, Real-time polymerase chain reaction, Nottingham Prognostic Index, Female, Fluorouracil, Protein determination, Regression analysis, Prognostic value, Ki67, Epirubicin, medicine.drug, Adult, Proportional hazards models, Disease-free survival, Histopathology, Breast Neoplasms, Young Adult, Antineoplastic combined chemotherapy protocols, Internal medicine, medicine, Early cancer, Human tissue, Racgap1, Oncogene, Proportional Hazards Models, Neoplastic, business.industry, Cancer survival, High risk patient, Young adult, Multivariate analysis, Rac gtpase activating protein 1, Multivariate Analysis, Rna, Ki 67 antigen, Prediction, business, Controlled study, Gene function

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4aeaf136db5f1bc63a52f742e8828fd7Test
https://doi.org/10.1007/s00280-012-2002-zTest

5

The maximum tolerated dose and biologic effects of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP) in combination with irinotecan for patients with refractory solid tumors

المؤلفون: Jens C. Eickhoff, Dona Alberti, James P. Thomas, Brian S. Choi, Jill M. Kolesar, S. Percy Ivy, George Wilding, Rebecca Marnocha, William R. Schelman, Kyle D. Holen

المصدر: Cancer Chemotherapy and Pharmacology. 66:973-980

مصطلحات موضوعية: Adult, Male, Thiosemicarbazones, Cancer Research, ATP Binding Cassette Transporter, Subfamily B, Maximum Tolerated Dose, Pyridines, Ribonucleotide reductase inhibitor, Pharmacology, Irinotecan, Toxicology, Article, chemistry.chemical_compound, Refractory, Pharmacokinetics, Neoplasms, Antineoplastic Combined Chemotherapy Protocols, medicine, Humans, Pharmacology (medical), ATP Binding Cassette Transporter, Subfamily B, Member 1, Glucuronosyltransferase, Chromatography, High Pressure Liquid, Aged, Polymorphism, Genetic, Dose-Response Relationship, Drug, biology, 3-Aminopyridine-2-carboxaldehyde thiosemicarbazone, Topoisomerase, Drug Synergism, Middle Aged, Treatment Outcome, Oncology, chemistry, Enzyme inhibitor, Toxicity, biology.protein, Camptothecin, Female, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0b3649594d9b53e5685d3a20d6eda61Test
https://doi.org/10.1007/s00280-010-1250-zTest

6

Effect of maximum-tolerated doses and low-dose metronomic chemotherapy on serum vascular endothelial growth factor and thrombospondin-1 levels in patients with advanced nonsmall cell lung cancer

المؤلفون: Hilal Oguz Soydinc, Meltem Selam, Irfan Cicin, Rian Disci, Kazim Uygun, Derya Duranyildiz, Faruk Tas, Erkan Topuz, Vildan Yasasever

المصدر: Cancer Chemotherapy and Pharmacology. 61:721-725

مصطلحات موضوعية: Adult, Male, Vascular Endothelial Growth Factor A, Oncology, Cancer Research, medicine.medical_specialty, Pathology, Lung Neoplasms, Time Factors, Maximum Tolerated Dose, Angiogenesis, medicine.medical_treatment, Enzyme-Linked Immunosorbent Assay, Docetaxel, Toxicology, Drug Administration Schedule, Thrombospondin 1, chemistry.chemical_compound, Carcinoma, Non-Small-Cell Lung, Internal medicine, Antineoplastic Combined Chemotherapy Protocols, medicine, Humans, Pharmacology (medical), Prospective Studies, Lung cancer, Aged, Neoplasm Staging, Pharmacology, Cisplatin, Chemotherapy, Vascular Endothelial Growth Factor Receptor-1, Dose-Response Relationship, Drug, Neovascularization, Pathologic, business.industry, Cancer, Middle Aged, medicine.disease, Metronomic Chemotherapy, Vascular endothelial growth factor, chemistry, Female, Taxoids, business, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e378219541685995d163fa8f8565ca84Test
https://doi.org/10.1007/s00280-007-0526-4Test

7

PAI-1 and HER2 interaction in advanced breast cancer disease: evidence for added benefit from trastuzumab in HER2-negative patients

المؤلفون: Dimosthenis Miliaras, Maria Sotiropoulou, Dimitrios Bafaloukos, Ioannis Efstratiou, Pavlos Papakostas, Georgia Karayannopoulou, Georgia Gourgioti, Anna Batistatou, Anna Koumarianou, Konstantine T. Kalogeras, George Pentheroudakis, Gerasimos Aravantinos, Evangelia Razis, Eleni Galani, Mattheos Bobos, Dimitrios Pectasides, George Fountzilas, Kalliopi Petraki, Haralabos P. Kalofonos

المصدر: Cancer chemotherapy and pharmacology. 75(6)

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf535a1ddcef6c316444d6f3c4df18d9Test
https://pubmed.ncbi.nlm.nih.gov/25947084Test

8

Interaction pharmacokinetics of pegylated liposomal doxorubicin (Caelyx) on coadministration with paclitaxel or docetaxel

المؤلفون: Briassoulis, E. Ch, Karavasilis, V., Tzamakou, E., Rammou, D., Soulti, K., Piperidou, C., Pavlidis, Nicholas

المساهمون: Pavlidis, Nicholas [0000-0002-2195-9961], Karavasilis, V. [0000-0002-5806-9399]

المصدر: Cancer chemotherapy and pharmacology

مصطلحات موضوعية: Male, Cancer Research, Docetaxel, Pharmacology, Toxicology, Polyethylene Glycols, Pegylated Liposomal Doxorubicin, Drug blood level, chemistry.chemical_compound, Doxorubicin/*administration & dosage/*pharmacokinetics, Controlled clinical trial, Antineoplastic Combined Chemotherapy Protocols, Drug Interactions, Pharmacology (medical), Paclitaxel/*administration & dosage, Quantitative analysis, Middle aged, Priority journal, Area under the curve, Liposome, biology, Polyethylene glycols, Middle Aged, Clinical trial, Antineoplastic agent, Oncology, Paclitaxel, Enzyme inhibitor, Female, Taxoids, Drug clearance, lipids (amino acids, peptides, and proteins), Drug carrier, Human, medicine.drug, Adult, Clinical article, Drug interaction, Data analysis, Article, Drug interactions, Pharmacokinetics, Antineoplastic combined chemotherapy protocols, Drug coating, Pegylated liposomal doxorubicin, Taxoid, medicine, Humans, Doxorubicin, Antineoplastic Combined Chemotherapy Protocols/*pharmacokinetics, Aged, Drug infusion, Taxane derivative, Phase 1 clinical trial, Taxoids/*administration & dosage, enzymes and coenzymes (carbohydrates), Malignant neoplastic disease, Macrogol, chemistry, Liposomes, Macrogol derivative, biology.protein, Cancer patient, Controlled study, High performance liquid chromatography

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acf8c01027ddb6014512733cf709d3b2Test
https://doi.org/10.1007/s00280-003-0750-5Test

9

A Phase Ib study evaluating MNRP1685A, a fully human anti-NRP1 monoclonal antibody, in combination with bevacizumab and paclitaxel in patients with advanced solid tumors

المؤلفون: Colin D. Weekes, Kyriakos P. Papadopoulos, Ron Yu, Vanitha Ramakrishnan, Amy Kim, Rainer K. Brachmann, Walter C. Darbonne, Amita Patnaik, Patricia LoRusso, Muralidhar Beeram, Wells A. Messersmith, L. Mason Shih, Lia Gore, Hong Xiang, Joseph Beyer, Yan Xin

المصدر: Cancer chemotherapy and pharmacology. 73(5)

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c73d55e93ba060152b8ed636dd70841Test
https://pubmed.ncbi.nlm.nih.gov/24633809Test

10

Phase I dose-escalation study of AZD7762, a checkpoint kinase inhibitor, in combination with gemcitabine in US patients with advanced solid tumors

المؤلفون: Richard Knight, Michael A. Carducci, Patricia LoRusso, Mary F. Quinn, Adrian M. Senderowicz, Patricia Oakes, Edward A. Sausville, Judith Carter, David Cosgrove, Felix Agbo, Nilofer S. Azad, Lisa Malburg, Sonya Zabludoff, Peter Barker

المصدر: Cancer chemotherapy and pharmacology. 73(3)

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51e92dc4add20634e1a0343a543997d4Test
https://pubmed.ncbi.nlm.nih.gov/24448638Test

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