Should EGFR mutations be tested in advanced lung squamous cell carcinomas to guide frontline treatment?
| العنوان: | Should EGFR mutations be tested in advanced lung squamous cell carcinomas to guide frontline treatment? |
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| المؤلفون: | Teh Ying Chou, Chao-Hua Chiu, Chun-Ming Tsai, Chi-Lu Chiang |
| المصدر: | Cancer Chemotherapy and Pharmacology. 74:661-665 |
| بيانات النشر: | Springer Science and Business Media LLC, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Genetic Markers, Oncology, Cancer Research, medicine.medical_specialty, Mutation rate, Consensus, Lung Neoplasms, medicine.drug_class, Antineoplastic Agents, Toxicology, Biomarkers, Pharmacological, Tyrosine-kinase inhibitor, Predictive Value of Tests, Carcinoma, Non-Small-Cell Lung, Internal medicine, medicine, Carcinoma, Humans, Pharmacology (medical), Genetic Testing, Epidermal growth factor receptor, Lung cancer, Pharmacology, biology, Molecular pathology, business.industry, Cancer, medicine.disease, ErbB Receptors, Mutation, Practice Guidelines as Topic, Carcinoma, Squamous Cell, Disease Progression, biology.protein, Adenocarcinoma, Drug Screening Assays, Antitumor, business |
| الوصف: | There is no argument over using epidermal growth factor receptor (EGFR) mutation status to guide the frontline treatment for advanced lung adenocarcinoma (LADC); however, the role of the testing in lung squamous cell carcinoma (LSQC) remains controversial. Currently, the guidelines/consensus statements regarding EGFR mutation testing in LSQC are not consistent among different oncology societies. American Society of Clinical Oncology recommends performing EGFR mutation testing in all patients; European Society for Medical Oncology, College of American Pathologists/International Association for the Study of Lung Cancer/Association for Molecular Pathology, and National Comprehensive Cancer Network suggest for some selected group. EGFR mutation is rarely found in LSQC; however, more importantly, it is not a valid predictive biomarker for EGFR tyrosine kinase inhibitors (EGFR-TKI) in LSQC as it has been shown in LADC. Available data showed that the response rate and progression-free survival in EGFR mutant LSQC patients treated with EGFR-TKI are not better than that observed in patients treated with platinum-doublet chemotherapy in the first-line setting. Therefore, in contrast to advanced LADC, EGFR mutation testing may not be necessarily performed upfront in advanced LSQC because not only the mutation rate is low, but also the predictive value is insufficient. For LSQC patients with known sensitizing-EGFR mutations, both conventional chemotherapy and EGFR-TKI are acceptable frontline treatment options. |
| تدمد: | 1432-0843 0344-5704 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68828fce87ac85333e3ef1f6a53a6118Test https://doi.org/10.1007/s00280-014-2536-3Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....68828fce87ac85333e3ef1f6a53a6118 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14320843 03445704 |
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