التفاصيل البيبلوغرافية
| العنوان: |
Capped-dose mitomycin C: a pooled safety analysis from three prospective clinical trials. |
| المؤلفون: |
Ntukidem, Nse, Arce-Lara, Carlos, Otterson, Gregory A., Kraut, Eric, Cataland, Spero, Bekaii-Saab, Tanios |
| المصدر: |
Cancer Chemotherapy & Pharmacology; Jan2010, Vol. 65 Issue 2, p319-324, 6p, 1 Diagram, 1 Chart |
| مصطلحات موضوعية: |
MITOMYCIN C, CLINICAL trials, DNA topoisomerase I, NEUTROPENIA, MEDICAL sciences |
| مستخلص: |
Mitomycin C (MMC) up-regulates topoisomerase-I and thymidine phosphorylase making it ideal to combine with irinotecan or capecitabine. One of the most devastating toxicities MMC has been associated with is thrombotic thrombocytopenic purpura/hemolytic uremic syndrome (TTP/HUS) in 4–15% of patients, especially when receiving cumulative doses higher than 60 mg/m2. We conducted a pooled safety analysis of 140 patients enrolled in three prospective clinical trials at our institution from 2001 to 2008. MMC on all our studies was capped to a cumulative dose of 36 mg/m2 to limit toxicity while retaining efficacy. We reviewed our electronic medical records and clinical trial database for individual patient data on these studies with a specific intent to identify patients meeting criteria for TTP/HUS. In combination with irinotecan or capecitabine, MMC was associated with manageable toxicities. We found no cases of MMC-associated TTP/HUS. There were no reported cardiac or pulmonary toxicities in our analysis. Most common grade 3/4 toxicities were diarrhea (19%), neutropenia (17%) and dehydration (12%) predominantly when MMC was combined with irinotecan. In this large pooled analysis, we found MMC, when capped at a cumulative dose of 36 mg/m2, to be safe and tolerable in combination with capecitabine or irinotecan with no reportable cases of TTP/HUS. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
