دورية أكاديمية
Identification of pharmacodynamic biomarkers and common molecular mechanisms of response to genotoxic agents in cancer cell lines.
| العنوان: | Identification of pharmacodynamic biomarkers and common molecular mechanisms of response to genotoxic agents in cancer cell lines. |
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| المؤلفون: | Min, Dong-Joon, Zhao, Yingdong, Monks, Anne, Palmisano, Alida, Hose, Curtis, Teicher, Beverly A, Doroshow, James H, Simon, Richard M |
| المصدر: | Cancer Chemother Pharmacol ; ISSN:1432-0843 ; Volume:84 ; Issue:4 |
| بيانات النشر: | Springer |
| سنة النشر: | 2019 |
| المجموعة: | PubMed Central (PMC) |
| مصطلحات موضوعية: | ER stress, Genotoxic agents, Pharmacodynamic biomarkers, Response mechanisms |
| الوصف: | Genotoxic agents (GAs) including cisplatin, doxorubicin, gemcitabine, and topotecan are often used in cancer treatment. However, the response to GAs is variable among patients and predictive biomarkers are inadequate to select patients for treatment. Accurate and rapid pharmacodynamics measures of response can, thus, be useful for monitoring therapy and improve clinical outcomes. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://doi.org/10.1007/s00280-019-03898-zTest; https://pubmed.ncbi.nlm.nih.gov/31367787Test; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8127867Test/ |
| DOI: | 10.1007/s00280-019-03898-z |
| الإتاحة: | https://doi.org/10.1007/s00280-019-03898-zTest https://pubmed.ncbi.nlm.nih.gov/31367787Test https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8127867Test/ |
| رقم الانضمام: | edsbas.AE18D7CA |
| قاعدة البيانات: | BASE |
| DOI: | 10.1007/s00280-019-03898-z |
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