A human icam-1 antibody isolated by a function-first approach has potent macrophage-dependent antimyeloma activity in vivo.
| العنوان: | A human icam-1 antibody isolated by a function-first approach has potent macrophage-dependent antimyeloma activity in vivo. |
|---|---|
| المؤلفون: | Veitonmäki, Niina, Hansson, Markus, Zhan, Fenghuang, Sundberg, Annika, Löfstedt, Tobias, Ljungars, Anne, Li, Zhan-Chun, Martinsson-Niskanen, Titti, Zeng, Ming, Yang, Ye, Danielsson, Lena, Kovacek, Mathilda, Lundqvist, Andrea, Mårtensson, Linda, Teige, Ingrid, Tricot, Guido, Frendéus, Björn |
| المصدر: | Cancer Cell. 23(4):502-515 |
| مصطلحات موضوعية: | Medicin och hälsovetenskap, Klinisk medicin, Cancer och onkologi, Medical and Health Sciences, Clinical Medicine, Cancer and Oncology |
| الوصف: | We isolated a tumor B-cell-targeting antibody, BI-505, from a highly diversified human phage-antibody library, using a pioneering "function-first" approach involving screening for (1) specificity for a tumor B cell surface receptor, (2) induction of tumor programmed cell death, and (3) enhanced in vivo antitumor activity compared to currently used treatments. BI-505 bound to intercellular adhesion molecule-1, identifying a previously unrecognized role for this receptor as a therapeutic target in cancer. The BI-505 epitope was strongly expressed on the surface of multiple myeloma cells from both newly diagnosed and relapsed patients. BI-505 had potent macrophage-dependent antimyeloma activity and conferred enhanced survival compared to currently used treatments in advanced experimental models of multiple myeloma. |
| الوصول الحر: | https://lup.lub.lu.se/record/3733600Test http://www.ncbi.nlm.nih.gov/pubmed/23597564?dopt=AbstractTest http://dx.doi.org/10.1016/j.ccr.2013.02.026Test |
| قاعدة البيانات: | SwePub |
| تدمد: | 18783686 |
|---|---|
| DOI: | 10.1016/j.ccr.2013.02.026 |