التفاصيل البيبلوغرافية
| العنوان: |
MicroRNA Signature Predicts Survival and Relapse in Lung Cancer |
| المؤلفون: |
Yu, Sung-Liang1,2,3, Chen, Hsuan-Yu2,4,5, Chang, Gee-Chen6,7, Chen, Chih-Yi8,9, Chen, Huei-Wen10, Singh, Sher11, Cheng, Chiou-Ling2, Yu, Chong-Jen12, Lee, Yung-Chie13, Chen, Han-Shiang14,15, Su, Te-Jen2,7, Chiang, Ching-Cheng2, Li, Han-Ni2, Hong, Qi-Sheng2, Su, Hsin-Yuan2, Chen, Chun-Chieh2, Chen, Wan-Jiun10, Liu, Chun-Chi7, Chan, Wing-Kai3, Chen, Wei J.2,4 |
| المصدر: |
Cancer Cell. Jan2008, Vol. 13 Issue 1, p48-57. 10p. |
| مصطلحات موضوعية: |
*LUNG cancer, *CANCER relapse, *RNA, *CANCER patients, *REVERSE transcriptase, *POLYMERASE chain reaction, *REGRESSION analysis |
| مستخلص: |
Summary: We investigated whether microRNA expression profiles can predict clinical outcome of NSCLC patients. Using real-time RT-PCR, we obtained microRNA expressions in 112 NSCLC patients, which were divided into the training and testing sets. Using Cox regression and risk-score analysis, we identified a five-microRNA signature for the prediction of treatment outcome of NSCLC in the training set. This microRNA signature was validated by the testing set and an independent cohort. Patients with high-risk scores in their microRNA signatures had poor overall and disease-free survivals compared to the low-risk-score patients. This microRNA signature is an independent predictor of the cancer relapse and survival of NSCLC patients. [Copyright &y& Elsevier] |
| قاعدة البيانات: |
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