Intake of dietary carbohydrates in early adulthood and adolescence and breast density among young women
| العنوان: | Intake of dietary carbohydrates in early adulthood and adolescence and breast density among young women |
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| المؤلفون: | Nola M. Hylton, Joanne F. Dorgan, John A. Shepherd, Linda Van Horn, Catherine Klifa, Seungyoun Jung, Linda Snetselaar, Erin S. LeBlanc, Olga Goloubeva |
| المصدر: | Cancer Causes Control |
| بيانات النشر: | Springer Science and Business Media LLC, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Adult, Dietary Fiber, Cancer Research, medicine.medical_specialty, Adolescent, Physiology, Breast Neoplasms, Article, 03 medical and health sciences, 0302 clinical medicine, Breast cancer, Risk Factors, Epidemiology, Glycemic load, Dietary Carbohydrates, medicine, Humans, 030212 general & internal medicine, Risk factor, Child, Breast Density, business.industry, Glycemic Load, Carbohydrate, medicine.disease, Magnetic Resonance Imaging, Diet, Glycemic index, Postprandial, Oncology, Glycemic Index, 030220 oncology & carcinogenesis, Female, business, Follow-Up Studies |
| الوصف: | PURPOSE: Carbohydrate intake increases postprandial insulin secretion and may affect breast density, a strong risk factor for breast cancer, early in life. We examined associations of adolescent and early adulthood intakes of total carbohydrates, glycemic index/load, fiber, and simple sugars with breast density among 182 young women. METHODS: Diet was assessed using three 24-h recalls at each of five Dietary Intervention Study in Children (DISC) clinic visits when participants were age 10–19 years and at the DISC06 Follow-Up Study clinic visit when participants were age 25–29 years. Associations between energy-adjusted carbohydrates and MRI-measured percent dense breast volume (%DBV) and absolute dense breast volume (ADBV) at 25–29 years were quantified using multivariable-adjusted mixed-effects linear models. RESULTS: Adolescent sucrose intakes and premenarcheal total carbohydrates intakes were modestly associated with higher %DBV (mean %DBV(Q1 vs Q4), 16.6 vs 23.5% for sucrose; and 17.2 vs 22.3% for premenarcheal total carbohydrates, all P(trend) ≤ 0.02), but not with ADBV. However, adolescent intakes of fiber and fructose were not associated with %DBV and ADBV. Early adulthood intakes of total carbohydrates, glycemic index/load, fiber, and simple sugars were not associated with %DBV and ADBV. CONCLUSIONS: Insulinemic carbohydrate diet during puberty may be associated with adulthood breast density, but our findings need replication in larger studies. Clinical Trials Registration ClinicalTrials.gov Identifier, NCT00458588 April 9, 2007; NCT00000459 October 27, 1999 |
| تدمد: | 1573-7225 0957-5243 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72823cdea73f84a8285aa92c1af01f65Test https://doi.org/10.1007/s10552-018-1040-1Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....72823cdea73f84a8285aa92c1af01f65 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15737225 09575243 |
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