التفاصيل البيبلوغرافية
| العنوان: |
Profiling of Tumor Microenvironment Components Identifies Five Stroma-Related Genes with Prognostic Implications in Colorectal Cancer. |
| المؤلفون: |
Liu, Jing-Wen1,2,3 (AUTHOR), Yu, Fei4 (AUTHOR), Tan, Yuan-Fei4 (AUTHOR), Huo, Jian-Ping1,2,3 (AUTHOR), Liu, Zhao5 (AUTHOR), Wang, Xiao-Jing6 (AUTHOR), Li, Jian-Ming1,2,3 (AUTHOR) ljwmelody@126.com |
| المصدر: |
Cancer Biotherapy & Radiopharmaceuticals. Dec2022, Vol. 37 Issue 10, p882-892. 11p. |
| مصطلحات موضوعية: |
*CARCINOGENESIS, *LOG-rank test, *CELL physiology, *COLORECTAL cancer, *STROMAL cells, *CANCER patients, *GENE expression profiling, *CANCER genes, *SURVIVAL analysis (Biometry), *KAPLAN-Meier estimator, *DESCRIPTIVE statistics, *STATISTICAL correlation, *DATA analysis software, *ALGORITHMS |
| مستخلص: |
Background: Tumor microenvironment (TME) significantly affects colorectal cancer (CRC) progression and therapeutic efficacy, particularly the infiltrating stromal components. This study profiled the TME composition of tumor tissue and identify TME-related, especially stroma-related genes having prognosis value in CRC patients. Materials and Methods: We used the ESTIMATE algorithm to assess stromal/immune component and divided 524 CRC cases of public dataset into high- and low-score groups. We analyzed the effect of the score on prognosis and extracted the differential expression genes (DEGs) between groups, which were stromal- and/or immune-related genes, and performed a prognostic investigation of the DEGs. Results: Higher stromal score correlated with poor survival, whereas the immune score was the inverse. By comparing global gene expression of cases with high vs. low stromal/immune scores, we extracted 474 stroma-related genes, 76 immune-related genes, and 498 intersection genes, which were explored by function enrichment and survival analysis. We identified the expression of five stroma-related genes (including ITGA7, PTPN14, SCG2, TNS1, and GRP) significantly associated with poorer survival, which were validated in the other two independent CRC cohorts. Conclusion: These results presented a comprehensive understanding of TME components and identified five stroma-related genes that predict poor outcomes in CRC patients. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
Academic Search Index |
