Tumor infiltrating T lymphocytes expressing FoxP3, CCR7 or PD-1 predict the outcome of prostate cancer patients subjected to salvage radiotherapy after biochemical relapse
| العنوان: | Tumor infiltrating T lymphocytes expressing FoxP3, CCR7 or PD-1 predict the outcome of prostate cancer patients subjected to salvage radiotherapy after biochemical relapse |
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| المؤلفون: | Maria Teresa Del Vecchio, Mariarosaria Boccellino, Leonardo Semeraro, Gaetano Facchini, Bruno Jim Rocca, Tommaso Carfagno, Luigi Pirtoli, Gianluca Vischi, Anna Grimaldi, Michele Caraglia, Massimiliano Berretta, Elodia Claudia Martino, Cirino Botta, Paolo Tini, Pierosandro Tagliaferri, Pierpaolo Correale, Pierfrancesco Tassone, Aurora Barone, Maria Raffaella Ambrosio, Valerio Nardone, Gabriella Misso |
| المساهمون: | Nardone, Valerio, Botta, Cirino, Caraglia, Michele, Martino, Elodia Claudia, Ambrosio, Maria Raffaella, Carfagno, Tommaso, Tini, Paolo, Semeraro, Leonardo, Misso, Gabriella, Grimaldi, Anna, Boccellino, Mariarosaria, Facchini, Gaetano, Berretta, Massimiliano, Vischi, Gianluca, Rocca, Bruno Jim, Barone, Aurora, Tassone, Pierfrancesco, Tagliaferri, Pierosandro, del Vecchio, Maria Teresa, Pirtoli, Luigi, Correale, Pierpaolo, Nardone V., Botta C., Caraglia M., Martino E.C., Ambrosio M.R., Carfagno T., Tini P., Semeraro L., Misso G., Grimaldi A., Boccellino M., Facchini G., Berretta M., Vischi G., Rocca B.J., Barone A., Tassone P., Tagliaferri P., del Vecchio M.T., Pirtoli L., Correale P. |
| المصدر: | Cancer Biology & Therapy. 17:1213-1220 |
| بيانات النشر: | Informa UK Limited, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, Oncology, Cancer Research, medicine.medical_treatment, Programmed Cell Death 1 Receptor, Chemokyne Receptor 7, Prostate cancer, 0302 clinical medicine, Recurrence, PD-1, Tumor Microenvironment, Forkhead Transcription Factors, hemic and immune systems, prostate cancer, Primary tumor, disease-free survival, FoxP3, overall survival, prognosis, radiotherapy, T regulators lymphocytes, tumor infiltrating lymphocytes, 030220 oncology & carcinogenesis, Molecular Medicine, prognosi, Research Paper, Receptors, CCR7, medicine.medical_specialty, chemical and pharmacologic phenomena, 03 medical and health sciences, Lymphocytes, Tumor-Infiltrating, Median follow-up, Internal medicine, Pharmacology, medicine, Humans, Progression-free survival, Radical surgery, Aged, Salvage Therapy, business.industry, Tumor-infiltrating lymphocytes, Prostatic Neoplasms, medicine.disease, Radiation therapy, T regulators lymphocyte, 030104 developmental biology, Tumor progression, tumor infiltrating lymphocyte, business |
| الوصف: | Tumor immunologic microenvironment is strongly involved in tumor progression and the presence of tumor infiltrating lymphocytes (TIL) with different phenotypes has been demonstrated to be of prognostic relevance in different malignancies. We investigated whether TIL infiltration of tumor tissues could also predict the outcome of prostate cancer patients. To this end, we carried out a retrospective analysis correlating the outcome of locally advanced prostate cancer patients undergone salvage radiotherapy upon relapse after radical surgery with the infiltration by different TIL populations. Twenty-two patients with resectable prostate cancer, with a mean age of 67 (+/−3.93) years, who received salvage radiotherapy with a mean of 69.66 (+/− 3.178) Gy in 8 weeks, between June 1999 and January 2009 and with a median follow up of 123 (+/− 55.82) months, were enrolled in this study. We evaluated, by immunohistochemistry, the intratumoral (t) and peripheral stroma (p) infiltration by CD45, CD3, CD4, CD8, CCR7, FoxP3 or PD-1-positive cells on tumor samples taken at the diagnosis (d) and relapse times (R). We correlated these variables with patients' biochemical progression free survival (bPFS), post-radiotherapy progression free survival (PFS), and overall survival (OS). Substantial changes in the rate of TIL subsets were found between the first and the second biopsy with progressive increase in CD4, CCR7, FoxP3, PD-1+ cells. Our analysis revealed that higher CD8p,R+ and lower PD-1R+ TIL scores correlated to a longer bPFS. Higher CD8p,R+ and CCR7t,R+ TIL scores and lower CD45p,R+ and FoxP3p,R+ TIL scores correlated to a prolonged PFS and OS. These results suggest that the immunological microenvironment of primary tumor is strictly correlated with patient outcome and provide the rationale for immunological treatment of prostate cancer. |
| تدمد: | 1555-8576 1538-4047 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b13e6241b6ab858dea12c198f1cd5dfaTest https://doi.org/10.1080/15384047.2016.1235666Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....b13e6241b6ab858dea12c198f1cd5dfa |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15558576 15384047 |
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