LAG-3 expression on tumor-infiltrating T cells in soft tissue sarcoma correlates with poor survival
| العنوان: | LAG-3 expression on tumor-infiltrating T cells in soft tissue sarcoma correlates with poor survival |
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| المؤلفون: | Xinke Zhang, Bu-Shu Xu, Huoying Chen, Jing Jing Zhao, Yao Liang, Wei Xiao, Mu Sheng Zeng, Xing Zhang, Zhixin Fang, Yuanxiang Guan, Yi Que |
| المصدر: | Cancer Biology & Medicine, Vol 16, Iss 2, Pp 331-340 (2019) Cancer Biology & Medicine |
| بيانات النشر: | China Anti-cancer Association, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | 0301 basic medicine, Cancer Research, Lymphocyte, CD3, lcsh:RC254-282, Flow cytometry, 03 medical and health sciences, 0302 clinical medicine, LAG-3, expression, medicine, Fibrosarcoma, Soft tissue sarcoma, biology, medicine.diagnostic_test, Tumor-infiltrating lymphocytes, business.industry, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, medicine.disease, 030104 developmental biology, medicine.anatomical_structure, Oncology, tumor-infiltrating lymphocytes, 030220 oncology & carcinogenesis, Cancer research, biology.protein, Immunohistochemistry, Original Article, prognosis, business, CD8 |
| الوصف: | Objective To elucidate the role and prognostic significance of lymphocyte activation-gene-3 (LAG-3) in soft tissue sarcoma (STS).Methods The expression of LAG-3 in patient and matched normal blood samples was analyzed by flow cytometry. The localization and prognostic values of LAG-3+ cells in 163 STS patients were analyzed by immunohistochemistry. In addition, the expression of tumor-infiltrating CD3+ T, CD4+ T, and CD8+ T cells and their role in the prognosis of STS were evaluated by immunohistochemistry. The effect of LAG-3 blockade was evaluated in an immunocompetent MCA205 fibrosarcoma mouse model.Results Peripheral CD8+ and CD4+ T cells from STS patients expressed higher levels of LAG-3 than those from healthy donors. LAG-3 expression in STS was significantly associated with a poor clinical outcome (P = 0.038 ) and was correlated with high pathological grade (P < 0.001), advanced tumor stage (P = 0.016). Additionally, LAG-3 expression was highly correlated with CD8+ T-cell infiltration (r = 0.7034, P < 0.001). LAG-3 was expressed in murine tumor-infiltrating lymphocytes, and its blockade decreased tumor growth and enhanced secretion of interferon-gamma by CD8+ and CD4+ T cells.Conclusions LAG-3 blockade may be a promising strategy to improve the effects of targeted therapy in STS. |
| تدمد: | 2095-3941 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7607db545de602cae003447afa493e7eTest https://doi.org/10.20892/j.issn.2095-3941.2018.0306Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....7607db545de602cae003447afa493e7e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20953941 |
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