التفاصيل البيبلوغرافية
| العنوان: |
Prognostic significance of copy number alterations in adolescent and adult patients with precursor B acute lymphoblastic leukemia enrolled in PETHEMA protocols. |
| المؤلفون: |
Ribera, Jordi, Morgades, Mireia, Zamora, Lurdes, Montesinos, Pau, Gómez‐Seguí, Inés, Pratcorona, Marta, Sarrà, Josep, Guàrdia, Ramon, Nomdedeu, Josep, Tormo, Mar, Martínez‐Lopez, Joaquin, Hernández‐Rivas, Jesús‐María, González‐Campos, José, Barba, Pere, Escoda, Lourdes, Genescà, Eulàlia, Solé, Francesc, Millá, Fuensanta, Feliu, Evarist, Ribera, Josep‐Maria |
| المصدر: |
Cancer (0008543X); Nov2015, Vol. 121 Issue 21, p3809-3817, 9p |
| مصطلحات موضوعية: |
ANTINEOPLASTIC agents, LYMPHOBLASTIC leukemia diagnosis, GENETICS, LYMPHOBLASTIC leukemia, GENETIC mutation, PROGNOSIS, PROTEINS, SURVIVAL, TREATMENT effectiveness, ACUTE diseases |
| مصطلحات جغرافية: |
SPAIN |
| مستخلص: |
Background: Some copy number alterations (CNAs) have independent prognostic significance for adults with acute lymphoblastic leukemia (ALL).Methods: This study analyzed via multiplex ligation-dependent probe amplification the frequency and prognostic impact of CNAs of 12 genetic regions in 142 adolescents and adults with de novo precursor B-cell ALL.Results: The cyclin-dependent kinase inhibitor 2A/B (CDKN2A/B) deletion (59 of 142 or 42%) was the most frequent CNA, and it was followed by Ikaros family zinc finger 1 (IKZF1) losses (49 of 142 or 35%). IKZF1 deletions were more prevalent in Philadelphia chromosome (Ph)-positive ALL and were associated with advanced age and high white blood cell (WBC) counts. The multivariate analysis showed that advanced age and early B-cell factor 1 (EBF1) deletions were associated with chemotherapy resistance in both the whole series (hazard ratios, 0.949 and 0.135, respectively) and the Ph-negative subgroup (hazard ratios, 0.946 and 0.118, respectively). High WBC counts and focal IKZF1 deletions correlated with disease recurrence (hazard ratios, 1.005 and 1.869, respectively), whereas advanced age and CDKN2A/B losses influenced overall survival in both the whole series (hazard ratios, 1.038 and 2.545, respectively) and the Ph-negative subgroup (hazard ratios, 1.044 and 2.105, respectively).Conclusions: Deletions of EBF1, IKZF1, and CDKN2A/B have an independent adverse prognosis for adolescents and adults with B-precursor ALL, and this suggests that these CNAs should be included in the initial risk assessment of ALL. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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