التفاصيل البيبلوغرافية
| العنوان: |
Integrin signaling in malignant melanoma. |
| المؤلفون: |
Silke Kuphal, Richard Bauer, Anja-Katrin Bosserhoff |
| المصدر: |
Cancer & Metastasis Reviews; Jun2005, Vol. 24 Issue 2, p195-222, 28p |
| مصطلحات موضوعية: |
MELANOMA, TUMORS, PROTEINS, MEMBRANE fusion |
| مستخلص: |
Abstract Cell adhesion and migration are essential for embryonic development, tissue regeneration, but also for tumor development. The physical link between the extracellular matrix (ECM) and the actin cytoskeleton is mainly mediated by receptors of the integrin family. Through signals transduced upon integrin ligation to ECM proteins, this family of proteins plays key roles in regulating tumor growth and metastasis as well as tumor angiogenesis. During melanoma development, changes in integrin expression, intracellular control of integrin functions and signals perceived from integrin ligand binding impact upon the ability of tumor cells to interact with their environment and enable melanoma cells to convert from a sessile, stationary to a migratory and invasive phenotype. Antagonists of several integrins are now under evaluation in clinical trials to determine their potential as therapeutics for malignant melanoma and other kinds of cancer. [ABSTRACT FROM AUTHOR] |
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Copyright of Cancer & Metastasis Reviews is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
