Immunohistochemical demonstration of epidermal growth factor in human gastric cancer xenografts of nude mice
| العنوان: | Immunohistochemical demonstration of epidermal growth factor in human gastric cancer xenografts of nude mice |
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| المؤلفون: | Keigo Nishi, Yasuhito Shimizu, Masao Akimoto, Norio Matsukura, Teruo Kiyama, Noritake Tanaka, Masahiko Onda, Akira Tokunaga, Goro Asano, Toshiro Yoshiyuki, Takashi Mizutani |
| المصدر: | Cancer. 65:953-957 |
| بيانات النشر: | Wiley, 1990. |
| سنة النشر: | 1990 |
| مصطلحات موضوعية: | Cancer Research, Pathology, medicine.medical_specialty, Stomach, Growth factor, medicine.medical_treatment, Cancer, Biology, medicine.disease, Transplantation, medicine.anatomical_structure, Oncology, Epidermal growth factor, Cell culture, Cancer cell, medicine, Immunohistochemistry |
| الوصف: | Thirty-two surgical specimens and three cell lines of human gastric cancers were used for subcutaneous transplantation into nude mice, resulting in the establishment of eight (25%) xenografts from the surgical specimens and two (67%) from the cell lines. The localization of epidermal growth factor (EGF) in the surgical specimens and cell lines of the gastric cancers and their xenografts in nude mice was then investigated immunohistochemically. Epidermal growth factor was stained in the cytoplasm of the cancer cells, being detected in 16 (50%) of the 32 surgical specimens and in all of the cell lines. Seven (44%) of the sixteen EGF-positive surgical specimens and one (6%) of the 16 EGF-negative ones were tumorigenic in nude mice. All of the xenografts in nude mice were positive for EGF. The tumorigenicity of human gastric cancer xenografts in nude mice may, therefore, be correlated with the presence of EGF in cancer cells. |
| تدمد: | 1097-0142 0008-543X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::f71eca1b2a380e037467630e2921fd24Test https://doi.org/10.1002/1097-0142Test(19900215)65:4<953::aid-cncr2820650422>3.0.co;2-g |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi...........f71eca1b2a380e037467630e2921fd24 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10970142 0008543X |
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