Prognostic factors for survival in patients with advanced renal cell carcinoma undergoing nonmyeloablative allogeneic stem cell transplantation
| العنوان: | Prognostic factors for survival in patients with advanced renal cell carcinoma undergoing nonmyeloablative allogeneic stem cell transplantation |
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| المؤلفون: | Rodrigo Martino, Tanner Demirer, Salvatore Siena, Paolo Pedrazzoli, Paolo Corradini, Gian Antonio Da Prada, Jacopo Peccatori, Lisbeth Barkholt, Paolo Bruzzi, Alberto Zambelli, Olle Ringden, Maria Pia Sormani, Fabio Ciceri, Stig Lenhoff, Gero Massenkeil, Giovanni Rosti, Dietger Niederwieser, Marco Bregni |
| المساهمون: | Peccatori, J, Barkholt, L, Demirer, T, Sormani, Mp, Bruzzi, P, Ciceri, Fabio, Zambelli, A, Da Prada, Ga, Pedrazzoli, P, Siena, S, Massenkeil, G, Martino, R, Lenhoff, S, Corradini, P, Rosti, G, Ringden, O, Bregni, M, Niederwieser, D. |
| المصدر: | Cancer. 104:2099-2103 |
| بيانات النشر: | Wiley, 2005. |
| سنة النشر: | 2005 |
| مصطلحات موضوعية: | Oncology, Cancer Research, medicine.medical_specialty, Allogeneic transplantation, Renal cell carcinoma, Internal medicine, Carcinoma, medicine, Humans, Transplantation, Homologous, Karnofsky Performance Status, Carcinoma, Renal Cell, Survival analysis, Univariate analysis, L-Lactate Dehydrogenase, Performance status, business.industry, Proportional hazards model, Prognosis, medicine.disease, Survival Analysis, Kidney Neoplasms, Surgery, Transplantation, C-Reactive Protein, business, Stem Cell Transplantation |
| الوصف: | BACKGROUND. The objective of this study was to identify prognostic factors for predicting survival in patients with advanced renal cell carcinoma (RCC) who had undergone an allogeneic stem cell transplantation after failure on immunotherapy. METHODS. The authors Studied 70 patients with advanced RCC Who underwent allogeneic transplantation with a fludarabine-based, reduced-intensity regimen. Ten parameters were analyzed at the time of transplantation for their power to predict Survival. Clinical features were examined first univariately; then, variables that were correlated significantly with Survival in the univariate analysis were included in a multivariate Cox regression model. RESULTS. Factors that were found to be associated significantly with limited survival were performance Status, the number of metastatic sites, the presence of mediastinal metastasis, hemoglobin level, C-reactive protein (CRP) level, lactate dehydrogenase (LDH) level, and neutrophil counts. All these variables were included in a multivariate Cox regression model, and three were retained in the final model. Patients were classified according to the score estimated by the final Cox model in two groups (above or below the median Value): The median Survival was 3.5 months for patients who had a poor prognosis patients versus 23 months for patients who had a good prognosis. CONCLUSIONS. The Current findings suggested that three easily available parameters (performance status, CRP level, and LDH level) could be used to stratify patients with advanced RCC who are candidates for allografting and to assist clinicians in decision-making and selection of an appropriate treatment program. (c) 2005 American Cancer Society. |
| تدمد: | 1097-0142 0008-543X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2368ccd221c1205a90d0b8d4b04e096Test https://doi.org/10.1002/cncr.21477Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....a2368ccd221c1205a90d0b8d4b04e096 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10970142 0008543X |
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