c-Met expression in tall cell variant papillary carcinoma of the thyroid
| العنوان: | c-Met expression in tall cell variant papillary carcinoma of the thyroid |
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| المؤلفون: | Zubair W. Baloch, Heather C. Nardone, Randal S. Weber, Rosemarie Mick, F J D Amy Ziober, M.P.H. Susan J. Mandel M.D., Virginia A. LiVolsi, Barry L. Ziober |
| المصدر: | Cancer. 98:1386-1393 |
| بيانات النشر: | Wiley, 2003. |
| سنة النشر: | 2003 |
| مصطلحات موضوعية: | Adult, Male, endocrine system, Cancer Research, Pathology, medicine.medical_specialty, C-Met, endocrine system diseases, Lymphovascular invasion, Proto-Oncogene Mas, Sensitivity and Specificity, Statistics, Nonparametric, Thyroid carcinoma, chemistry.chemical_compound, Culture Techniques, Biomarkers, Tumor, Carcinoma, medicine, Humans, Neoplasm Invasiveness, Thyroid Neoplasms, Aged, Probability, Analysis of Variance, business.industry, Thyroid disease, Thyroid, Cancer, Middle Aged, Proto-Oncogene Proteins c-met, Prognosis, medicine.disease, Immunohistochemistry, Thyroid Diseases, Carcinoma, Papillary, Gene Expression Regulation, Neoplastic, medicine.anatomical_structure, Oncology, chemistry, Case-Control Studies, Female, business |
| الوصف: | BACKGROUND Tall cell variant papillary carcinoma of the thyroid demonstrates unusually aggressive clinical behavior compared with the usual form of papillary thyroid carcinoma. The proto-oncogene c-met encodes a tyrosine kinase receptor known to influence cell invasion. This current study examined c-Met expression in tall cell variant tumors compared with other types of papillary thyroid carcinoma and benign thyroid disease. METHODS c-Met expression in 60 archived thyroid specimens was evaluated by immunohistochemical staining. RESULTS Tall cell variant specimens expressed significantly greater levels of c-Met than other forms of papillary thyroid carcinoma and benign thyroid disease (P < 0.0001). c-Met expression was significantly different for the following pairs of histologies: tall cell variant versus usual papillary carcinoma of the thyroid (P < 0.0001), tall cell variant versus follicular variant papillary thyroid carcinoma (P < 0.0001), tall cell variant versus benign thyroid (P < 0.0001), and usual papillary carcinoma of the thyroid versus benign thyroid (P = 0.005). In addition, for all types of papillary carcinomas evaluated, c-Met expression was significantly higher in specimens with extracapsular spread (P = 0.01) and skeletal muscle invasion (P = 0.02), and approached significance for specimens with lymphatic invasion (P = 0.06). After adjusting for extracapsular spread, c-Met expression was still found to be associated significantly with tall cell histology (P < 0.0001). CONCLUSIONS c-Met expression is a significant marker for tall cell variant papillary carcinoma of the thyroid and its invasive behavior. This finding may explain the unusually aggressive behavior of this tumor and suggests a role for c-Met in the early identification of patients with tall cell variant thyroid disease. Cancer 2003;98:1386–93. © 2003 American Cancer Society. DOI 10.1002/cncr.11638 |
| تدمد: | 1097-0142 0008-543X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5ab37634438bf22bf2dfe3bf9af811bTest https://doi.org/10.1002/cncr.11638Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....f5ab37634438bf22bf2dfe3bf9af811b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10970142 0008543X |
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