Dietary Patterns and Colorectal Adenomas in Lynch Syndrome The GEOLynch Cohort Study
| العنوان: | Dietary Patterns and Colorectal Adenomas in Lynch Syndrome The GEOLynch Cohort Study |
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| المؤلفون: | Fränzel J.B. Van Duijnhoven, Hans F. A. Vasen, Akke Botma, Ellen Kampman, Fokko M. Nagengast, Jan H. Kleibeuker |
| المساهمون: | Guided Treatment in Optimal Selected Cancer Patients (GUTS) |
| المصدر: | Cancer, 119(3), 512-521 Cancer, 119, 3, pp. 512-21 Cancer, 119, 512-21 Cancer 119 (2013) 3 Cancer, 119(3), 512-521. Wiley Cancer |
| بيانات النشر: | Wiley, 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | Male, Cancer Research, Nutrition and Disease, Colorectal cancer, DNA mismatch repair, population, Gastroenterology, FAMILIES, Cohort Studies, Risk Factors, Voeding en Ziekte, POPULATION, risk, Aged, 80 and over, RISK, education.field_of_study, Hazard ratio, COLON-CANCER, Middle Aged, families, Lynch syndrome, nutrition, Oncology, Cohort, endometrial cancer, Female, epidemiology, colon-cancer, Adenoma, Adult, medicine.medical_specialty, recurrence, Adolescent, Population, QUESTIONNAIRE, HNPCC, Colorectal adenoma, Diet Surveys, Young Adult, Translational research [ONCOL 3], Internal medicine, medicine, Humans, hereditary nonpolyposis, consumption, education, gene, RECURRENCE, Aged, Molecular epidemiology Aetiology, screening and detection [NCEBP 1], VLAG, Proportional hazards model, business.industry, questionnaire, Cancer, CONSUMPTION, Feeding Behavior, colorectal neoplasms, ENDOMETRIAL CANCER, medicine.disease, Colorectal Neoplasms, Hereditary Nonpolyposis, GENE, hnpcc, business, diet |
| الوصف: | BACKGROUND: Patients with Lynch syndrome (LS) have a high risk of developing colorectal cancer due to mutations in mismatch repair genes. Because dietary factors, alone and in combination, influence sporadic colorectal carcinogenesis, the association of dietary patterns with colorectal adenomas in LS patients was assessed. METHODS: In the GEOLynch cohort of 486 persons with LS, dietary information was collected, using a food frequency questionnaire. Dietary pattern scores were obtained by principal components analysis. Hazard ratios (HR) between dietary patterns and colorectal adenomas were calculated using Cox regression models. Robust sandwich variance estimates were used to control for dependency within families. Final models were adjusted for age, sex, smoking habits, colorectal adenoma history, and extent of colon resection. RESULTS: During a median follow-up of 20 months, colorectal adenomas were detected in 58 persons. Four dietary patterns were identified: a Prudent, Meat, Snack, and Cosmopolitan pattern. Individuals within the highest tertile of the Prudent pattern had a HR of 0.73 (95% confidence interval [CI], 0.32-1.66) for colorectal adenomas, compared with the lowest tertile. Those with high Meat pattern scores had a HR of 1.70 (95% CI, 0.83-3.52). A high Snack pattern was associated with an increased risk of colorectal adenomas (HR, 2.16; 95% CI, 1.03-4.49). A HR of 1.25 (95% CI, 0.61-2.55) was observed for persons in the highest tertile of the Cosmopolitan pattern. CONCLUSIONS: These findings suggest that dietary patterns may be associated with development of colorectal adenoma in patients with Lynch syndrome. The directions of these findings are corroborative with those observed in studies investigating sporadic colorectal cancer. Cancer 2013. (C) 2012 American Cancer Society. |
| وصف الملف: | application/pdf; application/octet-stream |
| اللغة: | English |
| تدمد: | 1097-0142 0008-543X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72efa4c77a0ad7ee1b7b180e9b445f34Test https://doi.org/10.1002/cncr.27726Test |
| حقوق: | RESTRICTED |
| رقم الانضمام: | edsair.doi.dedup.....72efa4c77a0ad7ee1b7b180e9b445f34 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10970142 0008543X |
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