Traumatic brain injury: Can the consequences be stopped?
| العنوان: | Traumatic brain injury: Can the consequences be stopped? |
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| المؤلفون: | Joshua D. Bell, Andrew J. Baker, Eugene Park |
| المصدر: | Canadian Medical Association Journal. 178:1163-1170 |
| بيانات النشر: | CMA Joule Inc., 2008. |
| سنة النشر: | 2008 |
| مصطلحات موضوعية: | medicine.medical_specialty, Traumatic brain injury, Glutamic Acid, Brain Edema, Diffuse Axonal Injury, Review, Receptors, N-Methyl-D-Aspartate, Pharmacological treatment, Intervention (counseling), medicine, Animals, Humans, Receptors, AMPA, Intensive care medicine, Calpain, Brain edema, business.industry, Diffuse axonal injury, General Medicine, medicine.disease, Axons, Brain Injuries, Anesthesia, Calcium, Intracranial Hypertension, Glutamic acid metabolism, business, Biomarkers |
| الوصف: | Traumatic brain injury is a leading cause of morbidity and death in both industrialized and developing countries. To date, there is no targeted pharmacological treatment that effectively limits the progression of secondary injury. The delayed progression of deterioration of grey and white matter gives hope that a meaningful intervention can be applied in a realistic timeframe following initial trauma. In this review we discuss new insights into the subcellular mechanisms of secondary injury that have highlighted numerous potential targets for intervention. |
| تدمد: | 1488-2329 0820-3946 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cdf5676a08ada18e09404d6aadd6dc6Test https://doi.org/10.1503/cmaj.080282Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....8cdf5676a08ada18e09404d6aadd6dc6 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14882329 08203946 |
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