المؤلفون: Jared Tur, Vijaykumar Sutariya, Nirmal S. Sharma, Kathleen Halasz, Robert Weigel, Shannon Kelly, Srinivas M. Tipparaju

المصدر: Canadian Journal of Physiology and Pharmacology. 97:675-684

مصطلحات موضوعية: 0301 basic medicine, Allergy, Physiology, Inflammation, 02 engineering and technology, Pharmacology, Fluticasone propionate, Cell Line, Mice, 03 medical and health sciences, chemistry.chemical_compound, Physiology (medical), medicine, Animals, Particle Size, Antipruritic, Drug Carriers, L-Lactate Dehydrogenase, business.industry, General Medicine, Hydrogen-Ion Concentration, 021001 nanoscience & nanotechnology, medicine.disease, In vitro, Drug Liberation, PLGA, 030104 developmental biology, chemistry, Drug delivery, Fluticasone, Nanoparticles, medicine.symptom, 0210 nano-technology, business, Glucocorticoid, medicine.drug

الوصف: Glucocorticoids, such as fluticasone propionate (FP), are used for the treatment of inflammation and alleviation of nasal symptoms and allergies, and as an antipruritic. However, both short- and long-term therapeutic use of glucocorticoids can lead to muscle weakness and atrophy. In the present study, we evaluated the feasibility of the nanodelivery of FP with poly(dl-lactide-co-glycolide) (PLGA) and tested in vitro function. FP-loaded PLGA nanoparticles were prepared via nanoprecipitation and morphological characteristics were studied via scanning electron microscopy. FP-loaded nanoparticles demonstrated an encapsulation efficiency of 68.6% ± 0.5% with a drug loading capacity of 4.6% ± 0.04%, were 128.8 ± 0.6 nm in diameter with a polydispersity index of 0.07 ± 0.008, and displayed a zeta potential of –19.4 ± 0.7. A sustained in vitro drug release pattern was observed for up to 7 days. The use of fluticasone nanoparticle decreased lipopolysaccharide (LPS)-induced lactate dehydrogenase release compared with LPS alone in C2C12 treated cells. FP also decreased expression of LPS-induced inflammatory genes in C2C12 treated cells as compared with LPS alone. Taken together, the present study demonstrates in vitro feasibility of PLGA-FP nanoparticle delivery to the skeletal muscle cells, which may be beneficial for treating inflammation.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b821dbf0604db42af05769d4899e8454Test
https://doi.org/10.1139/cjpp-2018-0569Test

المؤلفون: Ebru Çetin

المصدر: Canadian Journal of Physiology and Pharmacology. 97:407-412

مصطلحات موضوعية: Male, 0301 basic medicine, medicine.medical_specialty, Adult male, Physiology, Pharmacology toxicology, 030204 cardiovascular system & hematology, Rats, Sprague-Dawley, Ventricular Dysfunction, Left, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Physiology (medical), Internal medicine, medicine, Sprague dawley rats, Animals, cardiovascular diseases, Tilmicosin, Creatine Kinase, Pharmacology, L-Lactate Dehydrogenase, business.industry, General Medicine, Ghrelin, Rats, 030104 developmental biology, Endocrinology, chemistry, cardiovascular system, Tylosin, business

الوصف: This study was conducted to investigate the possible protective effects of ghrelin against tilmicosin-induced acute ventricular dysfunction in rats. Forty adult male Sprague Dawley rats were randomly divided into 4 equal groups: control, ghrelin, tilmicosin, and ghrelin + tilmicosin. The left ventricular structural and functional parameters together with cardiac biomarker levels were evaluated. The results showed that tilmicosin treatment alone significantly decreased the left ventricular fractional shortening, left ventricular ejection fraction, left ventricular stroke volume, and cardiac output when compared with control group. In addition, tilmicosin led to a significant increase in left ventricular internal dimension in systole and left ventricular fractional end-systolic volume. At the same time, serum lactate dehydrogenase, creatine kinase, and creatine kinase-myocardial B fraction levels were significantly increased in tilmicosin-treated group when compared with control group. However, ghrelin pretreatment significantly prevented the left ventricular internal dimension in systole, left ventricular fractional end-systolic volume, left ventricular stroke volume, left ventricular ejection fraction, left ventricular fractional shortening, and cardiac output changes caused by tilmicosin. Moreover, ghrelin pretreatment could reduce significantly serum lactate dehydrogenase, creatine kinase, and creatine kinase-myocardial B fraction levels. These data indicated that ghrelin treatment may provide a protective effect against tilmicosin-induced left ventricular systolic dysfunction.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5d0394ff6594af232ac501aad64f706Test
https://doi.org/10.1139/cjpp-2018-0511Test

المؤلفون: Pawel J. Winklewski, Natalia Kurhaluk, Bojková B

المصدر: Canadian Journal of Physiology and Pharmacology. 96:790-797

مصطلحات موضوعية: Male, 0301 basic medicine, Antioxidant, Carcinogenesis, Physiology, medicine.medical_treatment, Glutathione reductase, Mammary Neoplasms, Animal, Pharmacology, Diet, High-Fat, medicine.disease_cause, Antioxidants, Rats, Sprague-Dawley, Superoxide dismutase, Melatonin, 03 medical and health sciences, 0302 clinical medicine, Physiology (medical), TBARS, medicine, Animals, Aspartate Aminotransferases, Triglycerides, chemistry.chemical_classification, Reactive oxygen species, L-Lactate Dehydrogenase, biology, Chemistry, Alanine Transaminase, General Medicine, Aerobiosis, Metformin, Succinate Dehydrogenase, 030104 developmental biology, Liver, 030220 oncology & carcinogenesis, biology.protein, Female, Lipid Peroxidation, Oxidation-Reduction, Oxidative stress, medicine.drug

الوصف: Oxidative stress is involved in the development of various cancers. In the present study, the effect of long-term administration of peroral antidiabetic metformin and pineal hormone melatonin on liver antioxidant and aerobic status in female Sprague-Dawley rats carrying mammary tumors induced by N-methyl-N-nitrosourea was evaluated. Both substances were administered in a preventive and curative manner (12 days before and 16 weeks after the carcinogen application). Carcinogen administration induced oxidative stress: the level of thiobarbituric acid reactive substances (TBARS) considered as a marker of reactive oxygen species (ROS) generation in liver increased as well as the level of oxidatively modified protein content (OMP; aldehyde and ketone derivates). Metformin administration restored succinate dehydrogenase and lactate dehydrogenase activity and associated ROS production and OMP content to the level of intact rats, with predominant activation of superoxide dismutase (SOD) and glutathione reductase (GR). Melatonin alone and in combination with metformin also decreased TBARS content. OMP content decreased in all groups receiving chemoprevention. The rise in total antioxidant capacity after melatonin and particularly metformin and melatonin combination might result from the initiation of anaerobic metabolism and increasing SOD, GR, and glutathione peroxidase activity. Long-term administration of metformin and melatonin exerts antioxidant properties in liver, especially in combination.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::737d8390b7d80432e9bb5e03d294aec7Test
https://doi.org/10.1139/cjpp-2018-0001Test

المؤلفون: Lin Zhang, Yuan-Ming Lu, Zhi-Bin Yu, Jun Lee, Bo Jiao

المصدر: Canadian Journal of Physiology and Pharmacology. 95:59-71

مصطلحات موضوعية: Male, 0301 basic medicine, Physiology, Apoptosis, AMP-Activated Protein Kinases, 030204 cardiovascular system & hematology, Ventricular Function, Left, chemistry.chemical_compound, 0302 clinical medicine, Myocytes, Cardiac, Myocardial infarction, Phosphorylation, Creatine Kinase, biology, General Medicine, Hindlimb Suspension, Anesthesia, Cardiology, medicine.medical_specialty, Ischemia, Myocardial Reperfusion Injury, Thiophenes, Contractility, Necrosis, 03 medical and health sciences, Physiology (medical), Internal medicine, Lactate dehydrogenase, Autophagy, medicine, Animals, Muscle, Skeletal, Protein kinase A, Weightlessness Simulation, Pharmacology, L-Lactate Dehydrogenase, business.industry, Biphenyl Compounds, Body Weight, Hemodynamics, Isolated Heart Preparation, medicine.disease, Rats, Preload, 030104 developmental biology, chemistry, Pyrones, biology.protein, Creatine kinase, business, Reperfusion injury

الوصف: Gravitation is an important factor in maintaining cardiac contractility. Our study investigated whether simulated microgravity increases myocardial susceptibility to ischemia–reperfusion (IR) injury. Using the Langendorff-perfused heart model with 300 beats/min pacing, 4-week tail suspension (SUS) and control (CON) male Sprague-Dawley rats (n = 10 rats/group) were subjected to 60 min of left anterior descending coronary artery (LAD) occlusion followed by 120 min of reperfusion. Left ventricular end-systolic pressure (LVESP), left ventricular end-diastolic pressure (LVEDP), creatine kinase (CK) and lactate dehydrogenase (LDH) activity, and infarct size were assessed. Data demonstrated that there were significantly increased LVEDP, CK, LDH, and infarct size in SUS compared with CON (P < 0.05), accompanied by decreased LVESP (P < 0.05). Furthermore, TUNEL-positive cardiomyocytes were higher in SUS than that in CON (P < 0.01), and AMP-activated protein kinase (AMPK) phosphorylation and Bcl-2/Bax in SUS were less compared with CON (P < 0.05). Similarly, isolated hearts pre-treated with A-769662 exhibited better recovery of cardiac function, increased AMPK phosphorylation, and reduced necrosis and apoptosis. Furthermore, AMPKα protein showed a significant suppression in 4-week hindlimb unweighting rats. These results suggest that AMPK deficiency increases myocardial susceptibility to IR injury in rats subjected to simulated microgravity.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e4d1f25337cdde26268d9c6a081a709Test
https://doi.org/10.1139/cjpp-2015-0456Test

المؤلفون: Travis Webb, Kathleen Halasz, Robert Weigel, Rohini Nimbalkar, Kalyan C. Chapalamadugu, Srinivas M. Tipparaju, Jared Tur, Marco Brotto, Yashwant Pathak, Todd Daviau, Shannon Kelly, Vijaykumar Sutariya, Janice Cacace

المصدر: Canadian Journal of Physiology and Pharmacology. 96:681-689

مصطلحات موضوعية: 0301 basic medicine, Cell Survival, Physiology, Drug Compounding, Biological Availability, Inflammation, 02 engineering and technology, Pharmacology, Dexamethasone, Cell Line, Myoblasts, Mice, 03 medical and health sciences, chemistry.chemical_compound, Microscopy, Electron, Transmission, Polylactic Acid-Polyglycolic Acid Copolymer, Physiology (medical), Lactate dehydrogenase, medicine, Animals, Myocyte, Lactic Acid, Viability assay, Muscle, Skeletal, Glucocorticoids, Wound Healing, Myositis, Skeletal muscle, General Medicine, 021001 nanoscience & nanotechnology, Rats, Drug Liberation, PLGA, 030104 developmental biology, medicine.anatomical_structure, chemistry, Toxicity, Nanoparticles, medicine.symptom, 0210 nano-technology, Polyglycolic Acid, medicine.drug

الوصف: Glucocorticoids are utilized for their anti-inflammatory properties in the skeletal muscle and arthritis. However, the major drawback of use of glucocorticoids is that it leads to senescence and toxicity. Therefore, based on the idea that decreasing particle size allows for increased surface area and bioavailability of the drug, in the present study, we hypothesized that nanodelivery of dexamethasone will offer increased efficacy and decreased toxicity. The dexamethasone-loaded poly(lactic-co-glycolic acid) (PLGA) nanoparticles were prepared using nanoprecipitation method. The morphological characteristics of the nanoparticles were studied under scanning electron microscope. The particle size of nanoparticles was 217.5 ± 19.99 nm with polydispersity index of 0.14 ± 0.07. The nanoparticles encapsulation efficiency was 34.57% ± 1.99% with in vitro drug release profile exhibiting a sustained release pattern over 10 days. We identified improved skeletal muscle myoblast performance with improved closure of the wound along with increased cell viability at 10 nmol/L nano-dexamethasone-PLGA. However, dexamethasone solution (1 μmol/L) was injurious to cells because the migration efficiency was decreased. In addition, the use of dexamethasone nanoparticles decreased lipopolysaccharide-induced lactate dehydrogenase release compared with dexamethasone solution. Taken together, the present study clearly demonstrates that delivery of PLGA-dexamethasone nanoparticles to the skeletal muscle cells is beneficial for treating inflammation and skeletal muscle function.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69b8af8b24913997b212efec48483875Test
https://doi.org/10.1139/cjpp-2017-0795Test

المؤلفون: Cristiani F. Bortolatto, Cristiano Ricardo Jesse, Angélica S. Reis, Lucielli Savegnago, Silvane Souza Roman, Cristiane Luchese, Mikaela P. Pinz, Ethel A. Wilhelm

المصدر: Canadian Journal of Physiology and Pharmacology. 95:1039-1045

مصطلحات موضوعية: Male, 0301 basic medicine, Antioxidant, Physiology, medicine.medical_treatment, Intraperitoneal injection, Thioacetamide, Pharmacology, medicine.disease_cause, complex mixtures, 03 medical and health sciences, chemistry.chemical_compound, Organoselenium Compounds, Physiology (medical), Lactate dehydrogenase, mental disorders, parasitic diseases, medicine, Animals, Rats, Wistar, General Medicine, Glutathione, Ascorbic acid, digestive system diseases, Rats, Oxidative Stress, 030104 developmental biology, Liver, chemistry, Biochemistry, Alkaline phosphatase, Lipid Peroxidation, Oxidative stress

الوصف: The aim of this study was to investigate whether (E)-2-benzylidene-4-phenyl-1,3-diselenole (BPD) protects against hepatotoxicity induced by thioacetamide (TAA). On the first day of treatment, male adult Wistar rats received BPD (10 or 50 mg·kg–1). On the second day, the rats received a single intraperitoneal injection of TAA (400 mg·kg–1). Twenty-four hours after TAA administration, biochemical determinations and liver histological analysis were carried out. BPD (50 mg·kg–1) reduced plasma aspartate and alanine aminotransferase, alkaline phosphatase, and lactate dehydrogenase activities increased by TAA exposure. Treatment with BPD was effective against increased lipid peroxidation levels and attenuated a decrease in hepatic reduced glutathione and ascorbic acid levels as well as an inhibition of glutathione peroxidase activity caused by TAA exposure. The higher dose of BPD protected against the inhibition of hepatic δ-aminolevulinic dehydratase activity induced by TAA. Finally, histopathological examination of the liver showed that BPD markedly ameliorated TAA-induced hepatic injury. In conclusion, BPD protected against hepatotoxicity and oxidative stress caused by TAA exposure in rats.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85444151484f6ab91bbaa4e52927e3a0Test
https://doi.org/10.1139/cjpp-2016-0118Test

المؤلفون: Xiaolin Qin, Xuan Tan, Shanggong Yu, Mingyan Wong, Liping Zhang, Hong Dan, Xiaohui Peng, Nianbai Fang

المصدر: Canadian Journal of Physiology and Pharmacology. 94:245-250

مصطلحات موضوعية: Male, 0301 basic medicine, medicine.medical_specialty, Physiology, Myocardial Ischemia, Nitric Oxide Synthase Type II, Apoptosis, Myocardial Reperfusion Injury, Pharmacology, Paeonia, Protective Agents, Antioxidants, Superoxide dismutase, 03 medical and health sciences, chemistry.chemical_compound, Downregulation and upregulation, Malondialdehyde, Physiology (medical), Lactate dehydrogenase, Animals, Medicine, Myocyte, Myocytes, Cardiac, RNA, Messenger, Rats, Wistar, Creatine Kinase, bcl-2-Associated X Protein, L-Lactate Dehydrogenase, biology, Plant Extracts, Superoxide Dismutase, business.industry, Myocardium, General Medicine, Glutathione, Rats, Surgery, Nitric oxide synthase, Disease Models, Animal, 030104 developmental biology, chemistry, biology.protein, Creatine kinase, business, Drugs, Chinese Herbal

الوصف: Moutan cortex (MC) is a traditional Chinese medicine with diverse biological effects. The present study was performed to investigate the effects of MC on myocardial ischemia/reperfusion (I/R) in rats and to explore its possible mechanisms. Sprague-Dawley rats were administered MC extract (1.98 g/kg, i.g.) for 14 days and underwent a subsequent open-chest procedure involving 30 min of myocardial ischemia and 60 min of reperfusion. The cardioprotective effect of MC was demonstrated by reduced infarct size and marked improvement in the histopathological examination. The increase in the activity of superoxide dismutase (SOD) and glutathione (GSH) as well as the reduction of malondialdehyde (MDA) indicated that MC effectively promoted the anti-oxidative defense system. Increased anti-oxidative defense was accompanied by decreased release of lactate dehydrogenase (LDH) and creatine kinase (CK). The reduction in TUNEL-positive myocytes demonstrated that MC decreased myocardial apoptosis. The mRNA expression of B cell leukemia-2 (Bcl-2) was upregulated by MC and the ratio of Bcl-2/Bcl-2-associated X protein (Bax) mRNA expression was increased. MC pretreatment decreased the mRNA expression of inducible nitric oxide synthase (iNOS). The data from this study suggest that MC exerted protective effects on acute myocardial I/R injury via anti-oxidative and anti-apoptotic activities.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dc8422714a0f87013b6d9613ff3cf4bTest
https://doi.org/10.1139/cjpp-2015-0168Test

المؤلفون: Ola A El-Gohary, Mona M. Allam

المصدر: Canadian Journal of Physiology and Pharmacology. 95:641-646

مصطلحات موضوعية: Male, 0301 basic medicine, medicine.medical_specialty, Physiology, Myocardial Infarction, 030204 cardiovascular system & hematology, medicine.disease_cause, Superoxide dismutase, Electrocardiography, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Physiology (medical), Internal medicine, Lactate dehydrogenase, Isoprenaline, medicine, Vitamin D and neurology, Animals, Rats, Wistar, Vitamin D, Pharmacology, chemistry.chemical_classification, biology, business.industry, Glutathione peroxidase, Isoproterenol, General Medicine, Glutathione, Rats, PPAR gamma, Oxidative Stress, 030104 developmental biology, Endocrinology, chemistry, biology.protein, Creatine kinase, business, Biomarkers, Oxidative stress, medicine.drug

الوصف: Infarct-like lesion induced by isoprenaline is a well-known model to study myocardial infarction (MI). Vitamin D has been shown to have anti-inflammatory and antioxidant effects. Recent studies highlighted cross talk between vitamin D and peroxisome proliferator-activated receptor gamma (PPAR-γ). The present study was designed to investigate the effect of pretreatment with vitamin D on the isoprenaline-induced infarct-like lesion in rats and the role of PPAR-γ as a novel mechanism in vitamin-D-mediated cardioprotective effect. Markers chosen to assess cardiac damage included serum level of creatine kinase (CK), lactate dehydrogenase (LDH), tumor necrosis factor-alpha (TNF-α), and interleukin-6 (IL-6). Cardiac contents of malondialdehyde (MDA), superoxide dismutase (SOD), and glutathione peroxidase (GSH) were also assessed. Furthermore, ECG monitoring and measurement of injury extension were carried out. Isoprenaline increased the level of cardiac enzymes, as well as inflammatory and oxidative stress biomarkers. In addition, it produced ST-segment elevation. Pretreatment with vitamin D significantly improved previous parameters. The prior treatment with bisphenol A diglycidyl ether (BADGE), a PPAR-γ antagonist, significantly attenuated the protective effect of vitamin D. In conclusion, vitamin D can be demonstrated as a promising cardioprotective agent in MI and PPAR-γ significantly contributes toward vitamin-D-mediated protection.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00d3f98b2dc374e58ddfbf96f1250a45Test
https://doi.org/10.1139/cjpp-2016-0150Test

المؤلفون: Fangling Sun, Ruyi Zhang, Lan Zhang, Lin Li, Xue-jing Sun

المصدر: Canadian Journal of Physiology and Pharmacology. 95:750-758

مصطلحات موضوعية: 0301 basic medicine, 1-Methyl-4-phenylpyridinium, Cell Survival, Physiology, Mutant, Apoptosis, Biology, Transfection, medicine.disease_cause, Flow cytometry, Protein Aggregates, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Glucosides, Cell Line, Tumor, Physiology (medical), Lactate dehydrogenase, Stilbenes, medicine, Humans, Viability assay, bcl-2-Associated X Protein, Membrane Potential, Mitochondrial, Pharmacology, medicine.diagnostic_test, Caspase 3, General Medicine, Molecular biology, In vitro, 030104 developmental biology, Proto-Oncogene Proteins c-bcl-2, Biochemistry, chemistry, alpha-Synuclein, Reactive Oxygen Species, 030217 neurology & neurosurgery, Oxidative stress

الوصف: Increasing evidence has solidified the involvement of α-synuclein (α-Syn) and neurotoxins in the pathogenesis of Parkinson’s disease (PD), suggesting a combination of genetic and environmental influences. 2,3,5,4′-Tetrahydroxystilbene-2-O-β-D-glucoside (TSG) is one of the main active components extracted from Polygonum multiflorum. The purpose of the present study was to investigate the effects of TSG on α-Syn aggregation, mitochondrial dysfunction, oxidative stress, and apoptosis in vitro. A53T mutant α-synuclein-transfected cells (A53T AS cells) plus MPP+ exposure were used as a complex cell model of PD. The expression of proteins was determined by Western blot assay. Flow cytometry was utilized to measure mitochondrial membrane potential and apoptosis. The results showed that MPP+ exposure for 24 h induced more severe damage in A53T AS cells than in vector control cells. Pretreatment of TSG for 24 h significantly increased the cell viability; decreased lactate dehydrogenase leakage; inhibited α-Syn over-expression and aggregation; elevated mitochondrial membrane potential; decreased reactive oxygen species, Bax/Bcl-2 ratio, and caspase-3 activity; and inhibited apoptosis in A53T AS cells exposed to MPP+. These results suggest that TSG may be an attractive candidate for PD therapy.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5594de11f2a39445b359623eafa06534Test
https://doi.org/10.1139/cjpp-2016-0209Test

المؤلفون: Waleed Barakat, Shimaa M. Elshazly, Amr A.A. Mahmoud

المصدر: Canadian Journal of Physiology and Pharmacology. 94:1170-1177

مصطلحات موضوعية: 0301 basic medicine, Pharmacology, Cardiotoxicity, biology, Physiology, business.industry, General Medicine, Glutathione, medicine.disease_cause, Malondialdehyde, Pentoxifylline, Superoxide dismutase, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, chemistry, Physiology (medical), Lactate dehydrogenase, medicine, biology.protein, Doxorubicin, business, Oxidative stress, medicine.drug

الوصف: Doxorubicin (DOX) possesses a broad-spectrum antineoplastic activity; however, its clinical application is impeded by cardiotoxicity. This study aimed to investigate the protective effect of pentoxifylline (PXF), which possesses antioxidant and anti-inflammatory properties against cardiotoxicity induced by a single high dose (15 mg/kg, i.p.) or multiple low doses (2.5 mg/kg, i.p., three times per week for 2 weeks) of DOX. At the end of the experimental period, the serum creatine kinase (CK)-MB and lactate dehydrogenase (LDH) activities were measured. The hearts were then removed for evaluating TNF-α, NO, malondialdehyde (MDA), and reduced glutathione (GSH) levels, superoxide dismutase (SOD) and catalase (CAT) activities, and the expression of iNOS, NF-κB, Fas ligand (FasL), and caspase-3. The administration of DOX in both dose regimens caused increases in serum CK-MB and LDH activities, in cardiac TNF-α, NO and MDA levels, as well as in the cardiac expression of iNOS, NF-κB, FasL and caspase-3, whereas it significantly reduced the cardiac GSH level, as well as SOD and CAT activities (P < 0.05). Prophylactic treatment of rats with PXF diminished DOX-induced alterations in theses parameters. Our results warrant the clinical use of PXF as an adjuvant therapy to abrogate cardiotoxicity of DOX and extend its clinical applications.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::882691bfe1492dbb5abcde793ba3a45bTest
https://doi.org/10.1139/cjpp-2016-0115Test