دورية أكاديمية
Combining Genetic Variants to Improve Risk Prediction for NAFLD and Its Progression to Cirrhosis: A Proof of Concept Study
| العنوان: | Combining Genetic Variants to Improve Risk Prediction for NAFLD and Its Progression to Cirrhosis: A Proof of Concept Study |
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| المؤلفون: | Umberto Vespasiani-Gentilucci, Chiara Dell’Unto, Antonio De Vincentis, Andrea Baiocchini, Marco Delle Monache, Roberto Cecere, Adriano Maria Pellicelli, Valerio Giannelli, Simone Carotti, Giovanni Galati, Paolo Gallo, Francesco Valentini, Franca Del Nonno, Davide Rosati, Sergio Morini, Raffaele Antonelli-Incalzi, Antonio Picardi |
| المصدر: | Canadian Journal of Gastroenterology and Hepatology, Vol 2018 (2018) |
| بيانات النشر: | Hindawi Limited, 2018. |
| سنة النشر: | 2018 |
| المجموعة: | LCC:Diseases of the digestive system. Gastroenterology |
| مصطلحات موضوعية: | Diseases of the digestive system. Gastroenterology, RC799-869 |
| الوصف: | Background & Aims. Identifying NAFLD patients at risk of progression is crucial to orient medical care and resources. We aimed to verify if the effects determined by different single nucleotide polymorphisms (SNPs) could add up to multiply the risk of NAFLD and NASH-cirrhosis. Methods. Three study populations, that is, patients diagnosed with NASH-cirrhosis or with noncirrhotic NAFLD and healthy controls, were enrolled. PNPLA3 rs738409, TM6SF2 rs58542926, KLF6 rs3750861, SOD2 rs4880, and LPIN1 rs13412852 were genotyped. Results. One hundred and seven NASH-cirrhotics, 93 noncirrhotic NAFLD, and 90 controls were enrolled. At least one difference in allele frequency between groups was significant, or nearly significant, for the PNPLA3, TM6SF2, and KLF6 variants (p |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2291-2789 2291-2797 |
| العلاقة: | https://doaj.org/toc/2291-2789Test; https://doaj.org/toc/2291-2797Test |
| DOI: | 10.1155/2018/7564835 |
| الوصول الحر: | https://doaj.org/article/d4b60012130141539a87bcbfd040b534Test |
| رقم الانضمام: | edsdoj.4b60012130141539a87bcbfd040b534 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 22912789 22912797 |
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| DOI: | 10.1155/2018/7564835 |