Lung cancer and arsenic exposure in drinking water: a case-control study in northern Chile
| العنوان: | Lung cancer and arsenic exposure in drinking water: a case-control study in northern Chile |
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| المؤلفون: | Guillermo Marshall Gredis, Vivian Milosavjlevic Stat, Catterina Ferreccio, Ana María Sancha, Claudia Gonzalez Psych |
| المصدر: | Cadernos de Saúde Pública, Vol 14, Iss suppl.3, Pp 193-198 (1998) Cadernos de Saúde Pública, Vol 14, Iss suppl 3, Pp S193-S198 |
| بيانات النشر: | Escola Nacional de Saúde Pública, Fundação Oswaldo Cruz, 1998. |
| سنة النشر: | 1998 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Lung Neoplasms, Urban Population, lcsh:Medicine, Age and sex, Arsenic, Risk Factors, Water Supply, Surveys and Questionnaires, Internal medicine, medicine, Humans, Chile, Lung cancer, ARSENIC EXPOSURE, Lung, business.industry, lcsh:Public aspects of medicine, lcsh:R, Public Health, Environmental and Occupational Health, Case-control study, Cancer, lcsh:RA1-1270, Environmental exposure, Environmental Exposure, medicine.disease, Carcinogens, Environmental, Surgery, Health history, medicine.anatomical_structure, Case-Control Studies, Female, business, Water Pollutants, Chemical |
| الوصف: | In some Chilean cities, levels of arsenic (As) in drinking water reached 800 (micrograms/L between 1950 and 1970, while current levels are 40 (micrograms/L. To evaluate the causal role of this exposure in lung and bladder cancers, we conducted a case-control study in Regions I, II, and III of the country. From 1994 to 1996, cases diagnosed as lung cancer and two hospital controls were entered in the study; one control was a patient with a cancer, while the other was a patient without cancer, both conditions unrelated to As. Controls were matched with cases by age and sex. A standard survey containing questions about residence, employment, health history, was administered to study subjects. Data on As concentrations in water were obtained from records of the municipal water companies. A total of 151 lung cancer cases and 419 controls (167 with cancer and 242 without cancer) were enrolled. Median level of lifetime As exposure was significantly higher among cases, with a clear dose-response relationship between mean As exposure levels, with an OR (95% CI) of: 1, 1.7 (0.5-5.1), 3.9 (1.2-13.4), 5.5 (2.2-13.5), and 9.0 (3.6-22) for strata one to five respectively. This study provides new evidence that As in drinking water can cause internal cancers and gives an estimate of the form of this relationship. |
| اللغة: | English |
| تدمد: | 1678-4464 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16d4162f57451f33e684c29c33d17a3cTest http://www.scielosp.org/scielo.php?script=sci_arttext&pid=S0102-311X1998000700021Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....16d4162f57451f33e684c29c33d17a3c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16784464 |
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