Overview of mathematical approaches used to model bacterial chemotaxis I: The single cell
| العنوان: | Overview of mathematical approaches used to model bacterial chemotaxis I: The single cell |
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| المؤلفون: | Giorgio Gaglia, Steven L. Porter, Philip K. Maini, Marcus J. Tindall, Judith P. Armitage |
| المصدر: | Bulletin of Mathematical Biology. 70(6) |
| سنة النشر: | 2008 |
| مصطلحات موضوعية: | Pharmacology, Single model, Intracellular protein, General Mathematics, General Neuroscience, Chemotaxis, Immunology, Bacterial Physiological Phenomena, Biology, Models, Biological, General Biochemistry, Genetics and Molecular Biology, Cell biology, Phosphorylation cascade, Computational Theory and Mathematics, Escherichia coli, General Agricultural and Biological Sciences, Biological system, Cluster analysis, Algorithms, General Environmental Science, Signal Transduction |
| الوصف: | Mathematical modeling of bacterial chemotaxis systems has been influential and insightful in helping to understand experimental observations. We provide here a comprehensive overview of the range of mathematical approaches used for modeling, within a single bacterium, chemotactic processes caused by changes to external gradients in its environment. Specific areas of the bacterial system which have been studied and modeled are discussed in detail, including the modeling of adaptation in response to attractant gradients, the intracellular phosphorylation cascade, membrane receptor clustering, and spatial modeling of intracellular protein signal transduction. The importance of producing robust models that address adaptation, gain, and sensitivity are also discussed. This review highlights that while mathematical modeling has aided in understanding bacterial chemotaxis on the individual cell scale and guiding experimental design, no single model succeeds in robustly describing all of the basic elements of the cell. We conclude by discussing the importance of this and the future of modeling in this area. © 2008 Society for Mathematical Biology. |
| اللغة: | English |
| تدمد: | 1522-9602 0092-8240 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd1f6ac06c285f3873f49a2cfa9d3df3Test http://ora.ox.ac.uk/objects/uuid:473d6e07-9900-4993-bf4d-a931c9f61d10Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....cd1f6ac06c285f3873f49a2cfa9d3df3 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15229602 00928240 |
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